Reference

Transdermal tapes containing clonidines and their stabilizers

Transdermal tapes containing clonidines and their stabilizers. (Nitto Electric Industrial Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 60069013 A2 19 Apr 1985 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: A61K009-70. APPLICATION: JP 83-178959 26 Sep 1983. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Transdermal tapes contain a layer of pressure-sensitive acrylic polymer (glass vitrification temp., -70°~-10°) bases contg. clonidine (I) [4205-90-7] (and/or its HCl salt [4205-91-8]) and 1 or more thiol compds. contg. OH and/o carboxyl group. I is stabilized by the thiol compds. Thus, 2-ethylhexyl acrylate 97 g and acrylic acid 3 g were polymd. in the presence of 0.3 g azobisisobutyronitrile. To this acrylic polymer soln. were added I and 2-mercaptopropionic acid [79-42-5], and spread over a polyurethane film and dried. The transdermal antihypertensive tape was stable when stored 3 mo at 50°.

Transdermal tapes containing acrylic polymers

Transdermal tapes containing acrylic polymers. (Nitto Electric Industrial Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 60066759 A2 16 Apr 1985 Showa, 7 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: A61M037-00. ICS: A61F013-02; A61K009-70; A61L015-03. APPLICATION: JP 83-175618 21 Sep 1983. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Transdermal tapes consist of a carrier and an adhesive layer contg. drugs, homo- or copolymers of CH2:CHX and/or CH2:CRCO2X (R = H or Me; X = org. group contg. N or both N and O). Drugs are effectively released from the patch and the patch adheres firmly to the skin. Thus, 15 parts poly(vinylpyrrolidone) [9003-39-8] was dissolved in 85 parts CH2Cl2. 2-Ethylhexyl acrylate 93 and 2-hydroxyethyl acrylate 7 parts were polymd. in the presence of 0.1 part azobis(isobutyronitrile). The poly(vinylpyrrolidone) soln. and the acrylic copolymer soln. () were mixed, and clonidine-HCl [4205-91-8] in MeOH was added. The mixt. was spread on a 12-mm thick polyester film and dried. The adhesive layer was 50 mm thick when dried.