CAS No.4205-91-8,Clonidine hydrochloride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	4205-91-8
Name:	Clonidine hydrochloride

Formula:	C₉H₁₀Cl₃N₃
Molecular Weight:	266.558
Synonyms:	1H-Imidazol-2-amine,N-(2,6-dichlorophenyl)-4,5-dihydro-, monohydrochloride (9CI);2-Imidazoline,2-(2,6-dichloroanilino)-, monohydrochloride (8CI);2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride;2-[(2,6-Dichlorophenyl)amino]-2-imidazoline hydrochloride;2-[(2,6-Dichlorophenyl)amino]-2-imidazoline monohydrochloride;Atensina;Capresin;Catapres;Catapresan;Chlophazolin;Clofelin;Clonidine chloride;1H-Imidazol-2-amine,N-(2,6-dichlorophenyl)-4,5-dihydro-, hydrochloride (1:1);Clonidine monohydrochloride;Clopheline;DCAI;Haemiton;Hemiton;Isoglaucon;Katapresan;Neuclon;Normopresan;ST 155;
EINECS:	224-121-5
Melting Point:	312 °C
Boiling Point:	319.3 °C at 760 mmHg
Flash Point:	146.9 °C
Solubility:	Soluble in water (50 mg/ml), DMSO (75 mM), methanol, chloroform (slightly), and dehydrated alcohol.
Hazard Symbols:	T+
Risk Codes:	25-26
Safety:	22-26-28-36/37/39-45
Transport Information:	UN 2811 6.1/PG 1
PSA:	36.42000
LogP:	3.00390

Synthetic route

: 608-31-1
2,6-Dichloroaniline

: 4205-91-8
clonidine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 6.5 h / 100 °C 2: thionyl chloride; sulfuryl dichloride / 22 h / 60 °C 3: ethylenediamine / dichloromethane / 2 h / 5 - 20 °C 4: hydrogenchloride / ethanol; water / 0.83 h / Reflux View Scheme

: 10113-35-6
N-(2,6-dichlorophenyl)-formamide

: 4205-91-8
clonidine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: thionyl chloride; sulfuryl dichloride / 22 h / 60 °C 2: ethylenediamine / dichloromethane / 2 h / 5 - 20 °C 3: hydrogenchloride / ethanol; water / 0.83 h / Reflux View Scheme

: 4205-90-7
Clonidin

: 4205-91-8
clonidine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 0.833333h; Time; Reflux;	51.2 g

: 4205-91-8
clonidine hydrochloride

: 4205-90-7
Clonidin

Conditions

Conditions	Yield
With sodium hydroxide In water at 50℃;	94%

: 4205-91-8
clonidine hydrochloride

: N-nitrosoclonidine

Conditions

Conditions	Yield
With perchloric acid; Monochloroacetate buffer; cis-nitrous acid at 25℃; Rate constant; Mechanism; var. conc. of nitrous acid and clonidine hydrochloride; other buffers;

Raw Materials

103-80-0

120-93-4

825-43-4

608-31-1

60-80-0

5391-39-9

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Chemistry

IUPAC Name: N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride
Empirical Formula: C₉H₁₀Cl₃N₃
Molecular Weight: 266.5548g/mol
EINECS: 224-121-5
Structure of Clonidine hydrochloride (CAS NO.4205-91-8):

Flash Point: 146.9 °C
Enthalpy of Vaporization: 56.09 kJ/mol
Melting Point: 312 °C
Boiling Point: 319.3 °C at 760 mmHg
Vapour Pressure: 0.000342 mmHg at 25°C
solubility: H₂O: 50 mg/mL, clear, colorless
Product Categories: Adrenoceptor
Canonical SMILES: C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl
InChI: InChI=1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
InChIKey: ZNIFSRGNXRYGHF-UHFFFAOYSA-N

Uses

Clonidine has been prescribed historically as an antihypertensive agent. It has found new uses, including treatment of some types of neuropathic pain, opioid detoxification, sleep hyperhidrosis, anaesthetic use, and off-label, to counter the side effects of stimulant medications such as methylphenidate or amphetamine. It is becoming a more accepted treatment for insomnia, as well as for relief of menopausal symptoms. Clonidine(4205-91-8) is increasingly used in conjunction with stimulants to treat attention-deficit hyperactivity disorder (ADHD), for which it is administered in late afternoon or evening for sleep, and because it sometimes helps moderate ADHD-associated impulsive and oppositional behavior, and may reduce tics. Clonidine(4205-91-8) can be used in the treatment of Tourette syndrome. Clonidine(4205-91-8) is also a mild sedative, and can be used as premedication before surgery or procedures.

Toxicity Data With Reference

1.	orl-inf TDLo:390 µg/kg	PEDIAU Pediatrics. 72 (1983),500.
2.	orl-wmn TDLo:180 µg/kg:BAH,CVS,PUL	AJEMEN American Journal of Emergency Medicine. 7 (1989),343.
3.	orl-inf TDLo:390 µg/kg:NAH,CVS	PEDIAU Pediatrics. 72 (1983),500.
4.	orl-wmn TDLo:126 µg/kg/4 W-I:GIT	BMJOAE British Medical Journal. 292 (1986),174.
5.	orl-man TDLo:69 µg/kg:CNS,CVS	LANCAO Lancet. 2 (1976),694.
6.	orl-chd TDLo:70 µg/kg:CNS,CVS,PUL	AJDCAI American Journal of Diseases of Children. 137 (1983),171.
7.	orl-rat LD50:126 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),366.
8.	ipr-rat LD50:100 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 9 (1978),829.
9.	scu-rat LD50:77 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),366.
10.	ivn-rat LD50:29 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 16 (1966),1038.
11.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: coma, effects on sleep, fall in blood pressure, gastrointestinal system effects, increase in pulse rate, pulse rate decrease, reduced blood pressure, respiratory depression, respiratory system effects, somnolence. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and Cl⁻.
Hazard Codes: Very T+
Risk Statements: 25-26
R25 :Toxic if swallowed.
R26:Very toxic by inhalation.
Safety Statements: 22-26-28-36/37/39-45
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: NJ2490000
F: 10
HazardClass: 6.1(b)
PackingGroup: III

Specification

Clonidine hydrochloride , its cas register number is 4205-91-8. It also can be called 2-((2,6-Dichlorophenyl)amino)-2-imidazoline hydrochloride ; Apo-Clonidine ; Benzenamine, 2,6-dichloro-N-2-imidazolidinylidene-, hydrochloride ; Capresin ;
Catapresan ; Chlophazolin ; Clonidine HCl ; Clonidine hydrochloride ; Clonidine monohydrochloride ; Dixarit ; Edolglau ;
Ipotensium ; Katapresan ; Normopresan ; Novo-Clonidine ; Nu-Clonidine ; Trialox .