Detail of "4213-45-0"

CAS Number:
4213-45-0
Name:
1,4-Pentanediamine,N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxy-9-acridinyl)-, hydrochloride(1:2)
Molecular Structure:
Formula:
C23H28 Cl3 N3 O . 2 Cl H
Molecular Weight:
541.81
Synonyms:
1,4-Pentanediamine,N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxy-9-acridinyl)-, dihydrochloride(9CI); Acridine,9-[[4-[bis(2-chloroethyl)amino]-1-methylbutyl]amino]-6-chloro-2-methoxy-,dihydrochloride (6CI,7CI,8CI);2-Methoxy-6-chloro-9-[4-bis[2-chloroethyl]amino-1-methylbutyl amino)acridine dihydrochloride;ICR 10; NSC 3424; Quinacrine mustard; Quinacrine mustard dihydrochloride
Safety:
Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. Corrosive. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. See also QUINACRINE MUSTARD. Details

Display：

Quinacrine mustard dihydrochloride

Verified-Platinum Supplier 2nd Year Platinum
Supplier 1575 Integral
1575

Tel:86-311-67697318/86-311-67697368

Address:Tianjin, CHINA

Supplier:Shijiazhuang SuTe trade Co.,LTD [ China (Mainland)]

Verified-Platinum Supplier 1st Year Platinum
Supplier 930 Integral
930

Tel:+86-311-89643238

Address:No.19 pingan North street,Qiaodong District,Shijiazhuang,P.R. China

Supplier:Research Organics, Inc. [ United States]

610 Integral
610

Tel:216-883-8025

Address:4353 East 49th Street Cleveland, OH. 44125

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Cytogenetic assays of chemical clastogens using mammalian cells in culture: Cytogenetic assays of chemical clastogens using mammalian cells in culture. Hus, T. C.; Collie, Cheryl J.; Lusby, Andrea F.; Johnston, Dennis A. (Univ. Texas Syst. Cancer Cent., M. D. Anderson Hosp. Tumor Inst., Houston, Tex., USA). Mutat. Res., 45(2), 233-47 (English) 1977. CODEN: MUREAV. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) A protocol is described for cytogenetic assays of chem. mutagens using mammalian cells in vitro. The system employs continuous drug treatment (3 concns.) for up to 8 h and recovery-cell populations after pulse treatments with a high dose. Both direct fixation (for recording spindle anomalies in anaphase) and colcemid-hypotonic fixation (for reading metaphase chromosome aberrations) are used in order to est. the effects of an agent as a mitotic poison and as a clastogen resp. Some DNA intercalating dyes (acridine orange [65-61-2], quinacrine mustard [4213-45-0], neutral red [553-24-2]) were found to be highly clastogenic whereas others (quinacrine dihydrochloride [69-05-6], 33258 Hoechst [23491-45-4]) are not.

The temperature and time factors in caffeine potentiation of chemically-induced chromosomal aberrations in root tips of Vicia faba: The temperature and time factors in caffeine potentiation of chemically-induced chromosomal aberrations in root tips of Vicia faba. Sturelid, S.; Kihlman, B. A. (Dep. Genet. Plant Breed., Swed. Univ. Agric. Sci., Uppsala, Swed.). Hereditas, 88(1), 27-33 (English) 1978. CODEN: HEREAY. ISSN: 0018-0661. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Caffeine (I) [58-08-2] potentiation of chromosomal aberrations induced in V. faba root tips by maleic hydrazide [123-33-1], azaserine [115-02-6], methyl methanesulfonate [66-27-3], or dimethyl sulfate [77-78-1] was independent of the temp. (10-25°) during I exposure and of the time interval (0-6 h) between inducer and I treatment. I potentiation of ethyl methanesulfonate [62-50-0], N-methyl-N-nitrosourea [684-93-5], N-methyl-N'-nitro-N-nitrosoguanidine [70-25-7], and quinacrine mustard [4213-45-0] induced aberrations increased with increasing temp. during I treatment but was independent of the time interval between inducer and I treatment. I potentiation of chromosome damage from 1,2,3,4-diepoxybutane [1464-53-5], di(2-chloroethyl)methylamine-HCl [55-86-7], mitomycin C [50-07-7], and thiotepa [52-24-4] was enhanced by increasing the temp. during I treatment and increasing the interval between inducer and I treatment from 0-1 to 5-6 h.