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Detail of "42399-49-5"

  • CAS Number:
  • 42399-49-5
  • Name:
  • 1,5-Benzothiazepin-4(5H)-one,2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S,3S)-

  • Superlist Name:
  • (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • Molecular Structure:
  • Formula:
  • C16H15NO3S
  • Molecular Weight:
  • 301.36
  • Synonyms:
  • 1,5-Benzothiazepin-4(5H)-one,2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S-cis)-;(2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one;
  • EINECS:
  • 255-799-0
  • Density:
  • 1.303 g/cm3
  • Melting Point:
  • 203-206 °C(lit.)
  • Boiling Point:
  • 545.4 °C at 760 mmHg
  • Flash Point:
  • 283.7 °C
  • Appearance:
  • white to slightly beige powder
  • Hazard Symbols:
  • IrritantXi
  • Risk Codes:
  • 36/37/38
  • Safety:
  • 26-36 Details

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Assay:98%

Supplier:Hangzhou Dayangchem Co., Ltd. [ China (Mainland)]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

intermediate of Diltiazem

Supplier:ORCHID CHEMICAL SUPPLIES LTD (OCS) [ China (Mainland)]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

(2S,3S)-(+)-3- hydroxy-2- (4- methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin- 4(5H)-one [ CIS- (+) -hydroxy lactam]

Supplier:Manus Aktteva Biopharma LLP [ India]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Packing 1) 50 kg in Fibre board / HDPE Drums 2) 340 kg in water resistant jumbo bag Storage Store in a cool dry place,protected from light. Purity Profile Glc-Assay Above 99.0% Stability & Storage 12 Months in full sealed containers End Use Interm

Supplier:Nandolia Organic Chemicals Pvt. Ltd. [ India]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

We can offer Cis Hydroxy Lactum an inetrmediate for Diltiazem (API), Please feel free to contact us at falconchem at gmail dot com, regards, Binu keshavan

Supplier:Falcon Chemicals [ India]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

(2S)-(cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-(5H)-one

Supplier:hangzhou minko chemical co。,ltd [ China (Mainland)]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

1.1 gram in stock of Specs ID AC-509/25001342.

Supplier:SPECS [ Netherlands]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Cis(+)Hydroxy Lactum

Supplier:Hangzhou Haojie Pharm & Chem Co., Ltd [ China (Mainland)]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

(2S-cis)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-

Supplier:lianyungang scipharm technology co.,ltd [ China (Mainland)]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Supplier:Shanghai Maigochem Co., Ltd. [ China (Mainland)]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Supplier:Amoli Organics Ltd [ India]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Supplier:Formax Chemicals Co., Ltd. [ China (Mainland)]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Supplier:Fabbrica Italiana Sintetici S.p.A. [ Italy]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Supplier:OriPlatform [ Singapore]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Supplier:China Aroma Chemical Co., Ltd [ China (Mainland)]

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CAS No.42399-49-5 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Supplier:Jiangsu Huarong Biotech Co., Ltd. [ China (Mainland)]

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Reference

The conformation and circular dichroism of chiral 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones and their acyclic precursors
The conformation and circular dichroism of chiral 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones and their acyclic precursors. Gawronski, Jacek; Babs, Wojciech; Grynkiewicz, Grzegorz (Fac. Chem., A. Mickiewicz Univ., Poznan 60780, Pol.). Pol. J. Chem., 65(5-6), 1095-100 (English) 1991. CODEN: PJCHDQ. ISSN: 0137-5083. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) The Cotton effects of the title compds. I (R1 = Ph, Me, p-MeOC6H4; R2 = H, OH, OAc; R3 = CH2CH2NMe2.HCl, H) and their acyclic precursor II (R1 = H, Et; R2 = H, b-D-glucopyranosyl) were detd. The strong Cotton effect in I is due to the chiral N-acylarylaminochromophore. In II, the Cotton effects are primarily due exciton coupling of the arom.In this experiment, several chemicals are used like 33286-22-5 and 42399-49-5 chromophores. The conformation were discussed with the aid of mol. mechanics calcns. .
Stereoselective synthesis of diltiazem via dynamic kinetic resolution
Mordant, Celine; Cano de Andrade, Cristina; Touati, Ridha; Ratovelomanana-Vidal, Virginie; Ben Hassine, Bechir; Genet, Jean-Pierre (Laboratoire de Synthese Selective Organique et Produits Naturels, UMR 7573 C.N.R.S., Ecole Nationale Superieure de Chimie de Paris, Paris 75231/05, Fr.). Synthesis, (15), 2405-2409 (English) 2003 Georg Thieme Verlag. CODEN: SYNTBF. ISSN: 0039-7881. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 63 An efficient synthesis of diltiazem has been developed using dynamic kinetic resoln. (DKR) as a key step. Me (2S,3S)-2-chloro-3-hydroxy-3-(4-methoxyphenyl)propionate was synthesized from a racemic mixt. of a-chloro-b-keto ester, with high anti-diastereoselectivity (92%) and enantioselectivity (95%), based on an asym. hydrogenation reaction with a chiral ruthenium(II) catalyst, simply prepd. by mixing [(1,2,5,6-h)-1,5-cyclooctadiene]bis[(1,2,3-h)-2-methyl-2-propenyl]ruthen ium with the atropisomeric ligand [(1S)-6,6'-Dimethoxy[1,1'-biphenyl]-2,2'-diyl]bis[diphenylphosphine]. By treatment of (+)-(aS,bS)-a-chloro-b-hydroxy-4-methoxybenzenepropanoic acid Me ester with a base, the corresponding Me trans-glycidate [i.e.In this experiment, several chemicals are used like 42399-49-5 and 100-06-1 , (-)-(2R,3S)-3-(4-methoxyphenyl)oxiranecarboxylic acid Me ester], a key intermediate of diltiazem, was easily obtained. .
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