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Reference

Benzolactam growth hormone secretagogues: replacement of the C-3 amide bond in L-692,429

Benzolactam growth hormone secretagogues: replacement of the C-3 amide bond in L-692,429. Ok, Hyun O.; Szumiloski, John L.; Doldouras, George A.; Schoen, William R.; Cheng, Kang; Chan, Wanda W.-S.; Butler, Bridget S.; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J. (Departments Medicinal Chemistry Biochemistry Physiology, Merck Research Laboratories, Rahway, NJ 07065, USA). Bioorganic & Medicinal Chemistry Letters, 6(24), 3051-3056 (English) 1996 Elsevier. CODEN: BMCLE8. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1, 25 The synthesis and structure-activity relationships of various C-3 amide bond modifications in the novel non-peptidyl growth hormone secretagogue L-692,429 (I) were described. 187107-77-3 which is the cas registry number of some chemical is mentioned. An example deriv. was II. Several C-3 amide surrogates were prepd. and the urea moiety was found to exhibit growth hormone releasing activity similar to that obsd. with L-692,429. .