Detail of "4252-78-2"

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CAS Number:
4252-78-2
Name:
Ethanone,2-chloro-1-(2,4-dichlorophenyl)-
Superlist Name:
2,2',4'-Trichloroacetophenone
Molecular Structure:
Formula:
C₈H₅Cl₃O
Molecular Weight:
223.48
Synonyms:
Acetophenone,2,2',4'-trichloro- (6CI,7CI,8CI);2,4,2'-Trichloroacetophenone;2,4-Dichlorophenacyl chloride;2-Chloro-1-(2,4-dichlorophenyl)ethanone;2-Chloro-1-(2',4'-dichlorophenyl)ethanone;Chloromethyl 2,4-dichlorophenylketone;a,2,4-Trichloroacetophenone;w-Chloro-2,4-dichloroacetophenone;
EINECS:
224-218-2
Density:
1.43 g/cm³
Melting Point:
47-54 °C(lit.)
Boiling Point:
292.2 °C at 760 mmHg
Flash Point:
122.1 °C
Solubility:
Insoluble in water
Appearance:
yellow crystalline powder
Hazard Symbols:
Xi,C,N, T
Risk Codes:
37/38-41-43-51/53-34-23/24/25
Safety:
26-36/37/39-61-45 Details
Transport Information:
UN 1759

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Reference

Antimycotic hydroxyalkynylazolyl derivatives: Antimycotic hydroxyalkynylazolyl derivatives.Some chemicals with cas registry numbers like 89392-39-2 and 89392-61-0 are also used. Jaeger, Gerhard; Boeckmann, Klaus; Buechel, Karl Heinz; Plempel, Manfred (Bayer A.-G. , Fed. Rep. Ger.). Ger. Offen. DE 3222166 A1 15 Dec 1983, 45 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-41; A61K031-415; C07D249-08; C07D239-60. APPLICATION: DE 82-3222166 12 Jun 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 10, 28 I (A is N or CH; R is substituted alkyl, substituted cycloalkyl, or substituted phenyl; R1 is H, alkyl, alkenyl, alkynyl, or substituted benzyl; R2 is H or Me; and X is H, Br, or I) and their salts are effective in inhibiting fungi and yeasts in vitro and in treating candidiasis. Thus, proparygyl bromide [106-96-7] in THF contg. Al amalgam was cooled to -60° and mixed with w-chloro-2,4-dichloroacetophenone [4252-78-2], allowed to warm to 0°, hydrolyzed after 1 h with satd. aq. NH4Cl and worked up to give 5-chloro-4-(2,4-dichlorophenyl)-1-pentyn-4-ol [89393-00-0]. The product was added to boiling PrOH contg. imidazole [288-32-4], the soln. concd., extd. with EtOAc, and washed to give 4-(2,4-dichlorophenyl)-5-imidazolyl-1-pentyn-4-ol [89392-29-0], which inhibited a variety of fungi and yeasts and was very effective (90% survival) in treating mice infected with Candida albicans. Soln. and cream formulations are given. .

Metabolic demethylation of the insecticide dimethyl-vinphos in rats, in dogs, and in vitro: Metabolic demethylation of the insecticide dimethyl-vinphos in rats, in dogs, and in vitro. Crawford, Maureen J.; Hutson, D. H.; King, Pauline A. (Sittingbourne Res. Cent., Shell Res. Ltd., Sittingbourne, Engl.). Xenobiotica, 6(12), 745-62 (English) 1976. CODEN: XENOBH. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Following oral administration of 0.606 and 4.05 mg dimethylvinphos (I) [2274-67-1] to rats and dogs resp., I was metabolized via demethylation to desmethyl dimethylvinphos [60244-89-5] and then hydrolyzed to 2,4-dichlorophenacyl chloride (II) [4252-78-2] which was further metabolized to 2,4-dichloromandelic acid [7554-78-1], 1-(2,4-dichlorophenyl)ethanol [1475-13-4], and 2,4-dichlorophenylethanediol [14866-28-5], the latter 2 being conjugated with glucuronides. II was metabolized to 2,4-dichloroacetophenone [2234-16-4] by isolated rat liver microsomes and cytosol. In isolated liver fractions, I was demethylated by glutathione S-methyl transferase in the cytosol and microsomal monooxygenase. 4252-78-2 and 50812-37-8 are just another two chemicals used in this study. Phenobarbital pretreatment increased transferase activity 2-fold, and induced microsomal demethylation 45-fold, which resulted in a >13-fold protective effect against the acute toxic effects of I. .

Detail of "4252-78-2"

Ethanone,2-chloro-1-(2,4-dichlorophenyl)-

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CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

CAS No.4252-78-2 2,2',4'-Trichloroacetophenone

Reference