Detail of "42860-04-8"

Reference

Preparation of bicyclic derivatives as p38 kinase inhibitors

All Rights Reserved. Preparation of bicyclic derivatives as p38 kinase inhibitors. Almansa Rosales, Carmen; Virgili Bernado, Marina (J. Uriach y Compania S.Chemicals with cas numbers 918331-90-5 and 42860-04-8 also play role.A., Spain). PCT Int. Appl. WO 2007000339 A1 4 Jan 2007, 80pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-EP6255 28 Jun 2006. PRIORITY: EP 2005-380140 29 Jun 2005. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1, 25, 63 Title compds. represented by the formula I [wherein A = CR1R2 or NR3; R1, R2 = alkyl; R3, R8 = independently -(CH2)p-Cy1 or (un)substituted alkyl; m = 1 or 2; R4 = -B-R8; R5 = H, halo, alkyl or alkoxy; R6 = halo or Me; p = 0-2; Cy1 = (un)substituted Ph, heteroaryl, cycloalkyl or heterocyclyl; B = -CONR9-, -NR9CO- or -NR9CONR9-; R9 = H or alkyl; or salts thereof] were prepd. as p38 kinase inhibitors. For example, II was provided in a multi-step synthesis starting from 4-bromo-2-methylbenzoic acid. I showed more than 50 % inhibition for p38a enzyme activity at 10 mM. Thus, I are useful for the treatment of p38 kinase mediated diseases, such as immune diseases. .