Reference

A review of the pharmacology of nabumetone

A review of the pharmacology of nabumetone. Mangan, F. R. (Res. Div., Beecham Pharm., UK). Int. Congr. Symp. Ser. - R. Soc. Med., 69(Nabumetone: Novel Anti-Inflammatory), 5-14 (English) 1985. CODEN: RMISDU. ISSN: 0142-2367. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review with 12 refs. of the pharmacol. of BRL 14777 (I) [42924-53-8], a non-steroidal anti-inflammatory drug. The analgesic and antipyretic activities of I as well as its lack of gastric irritancy were also evaluated.

Nabumetone - a novel anti-inflammatory drug: bioavailability after different dosage regimens

Nabumetone - a novel anti-inflammatory drug: bioavailability after different dosage regimens. Von Schrader, H. W.; Buscher, G.; Dierdorf, D.; Muegge, H.; Wolf, D. (Beecham-Wuelfing Clin. Res. Dep., Neuss 4040, Fed. Rep. Ger.). Int. J. Clin. Pharmacol., Ther. Toxicol., 22(12), 672-6 (English) 1984. CODEN: IJCPB5. ISSN: 0300-9718. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The bioavailability of nabumetone [42924-53-8] after different multiple dosing regimens was investigated in healthy male volunteers by detg. the main plasma metabolite, 6-methoxy-2-naphthylacetic acid [23981-47-7]. The mean steady-state morning plasma level was higher when 1000 mg nabumetone was administered, once daily, at night than after the application of 500 mg twice daily (in the morning and in the evening). There was only a small further increase of the mean steady-state morning level when the dose was increased to 1000 mg twice daily. In all application regimens the steady state was reached on day 3. The dosages of 1000 mg, once daily, at night with and without a loading dose of 1000 mg on the morning of the 1st day were compared. When a loading dose was administered the plasma levels rose very quickly to higher values but reached the same mean on day 3 as when given without the loading dose. The half-lives of the terminal b-phase, with mean values of 22.77 h and 22.0 h, are of the same order of magnitude as those found in single-dose studies. A dose regimen of 1000 mg once daily, at night, would be preferable.