Reference

Preparation of 5-pyrazolecarboxamide derivatives with antibacterial activity in vitro

Preparation of 5-pyrazolecarboxamide derivatives with antibacterial activity in vitro. Tisselli Gualtieri, Eugenio; Garcia de la Mora, Gustavo (Fermic S.A. de C.V., Mex.). Mex. Pat. Appl. MX 9806522 A 28 Feb 2000, 13 pp. 42926-52-3 is the cas registry number. This chemical is also mentioned in this article. (Spanish). (Mexico). CODEN: MXXXA3. CLASS: ICM: C07D231-38. APPLICATION: MX 1998-98/6522 19980812. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 10 5-Pyrazolecarboxamide derivs. I [R1 = H, C1-C3 alkyl; R2 = C1-C3 alkyl; R3 = C1-C6 alkyl, Ph, (un)substituted aryl] and their pharmaceutically-acceptable compns. were prepd. for use as antibacterials. Thus, I (R1 = Me, R2 = Pr, R3 = o-EtOC6H4CO) was prepd. from Et 3-propyl-5-pyrazolecarboxylate by sequential methylation, sapon., nitration, amidation, redn., and acylation. The product showed complete inhibition of Staphylococcus aureus and Sarcina lutea and 0.5-1 mg/mL. .