Reference

The influence of a-tocopherol nicotinate (Renascin) on cardiac glycoside effects

The influence of a-tocopherol nicotinate (Renascin) on cardiac glycoside effects. Tawfik, H.; Schlieper, P. (Inst. Pharmacol., Univ.Chemicals with cas numbers 59-67-6 and 143-07-7 also play role. Duesseldorf, Duesseldorf, Fed. Rep. Ger.). Card. Glycosides 1785--1985, 109-17. Edited by: Erdmann, Erland; Greeff, Kurt; Skou, Jens C. Steinkopff: Darmstadt, Fed. Rep. Ger. (English) 1986. CODEN: 55MWAM. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) Section cross-reference(s): 18 The influence of Renascin (I) [43119-47-7] and related compds. on the effects of cardiac glycosides on isolated guinea-pig atria and on the glycoside binding to guinea-pig heart homogenate was investigated. I and dodecanoic acid [143-07-7] had an inhibitory effect on the pos. inotropic action of digoxin [20830-75-5] but not on that of ouabain [630-60-4]. This effect was parallel to their inhibitory effect of digoxin and not ouabain binding to heart homogenate. The tested compds. showed a protective effect against cardiac glycoside induced arrhythmias, there was no correlation between the protective action and their effects on the pos. inotropic action of the glycosides or on their binding to heart homogenate. The protective effect may be due to a direct action of the drugs on the cell membrane. .

Aqueous solutions containing fat-soluble vitamins

Aqueous solutions containing fat-soluble vitamins. (Ajinomoto Co., Inc.; Eisai Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 59104313 A2 16 Jun 1984 Showa, 10 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K009-10. ICA: A61K031-125; A61K031-355. APPLICATION: JP 82-212695 6 Dec 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 18 Fat-sol. vitamin E [1406-18-4] or vitamin K [12001-79-5] in therapeutic aq. solns. is stabilized by hydrogenated lecithins. Thus, 250 mg hydrogenated lecithin and 20 mL H2O were added to 250 mg vitamin E nicotinate [43119-47-7] and treated with ultrasonic waves (20 KH, 200 W) for 90 min under N gas. Then, 5 g sorbitol was added, and the total vol. adjusted with H2O to 100 mL. The mixt. was filtered and sterilized by heating to obtain an injection soln.