Detail of "433-17-0"

Reference

2-Benzothiazolesulfonamide derivatives for topical treatment of elevated ocular pressure

2-Benzothiazolesulfonamide derivatives for topical treatment of elevated ocular pressure. Desolms, S. Jane (Merck and Co., Inc. , USA). Eur. Pat. Appl. EP 122831 A2 24 Oct 1984, 50 pp. DESIGNATED STATES: R: CH, DE, FR, GB, IT, LI, NL. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: C07D277-80; A61K031-425. APPLICATION: EP 84-400524 14 Mar 1984. PRIORITY: US 83-476002 17 Mar 1983. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 63 2-Benzothiazolesulfonamides I (R = NH2, substituted amino), useful for the topical treatment of ocular hypertension (no data), were prepd. Thus, 2-mercapto-6-nitrobenzothiazole was treated with NaOCl and NH4OH to give the sulfenamide, which was oxidized with KMnO4 to give I (R = 6-NO2). This was hydrogenated in EtOH over 5% Pd-C to give I (R = 6-NH2), which was reductively alkylated with NaBH4 and HOAc to give I (R = 6-EtNH).In this study，7442-07-1 is also used. .