Reference

Vitamin E and human neuroblastoma

Vitamin E and human neuroblastoma. Helson, L.; Verma, M.; Helson, C. (Mem. Sloan-Kettering Cancer Cent., New York, NY 10021, USA). Modulation Mediation Cancer Vitam., [Proc. - Int. Conf.], 1st, Meeting Date 1982, 258-65. Edited by: Meyskens, Frank L.; Prasad, Kedar N. Karger: Basel, Switz. (English) 1983. CODEN: 51AEAG. DOCUMENT TYPE: Conference CA Section: 18 (Animal Nutrition) Section cross-reference(s): 1 Human neuroblastoma cell lines SK-N-(LO, DZ, AS, RA, FL, and CH) were inhibited by vitamin E compds.; higher water soly. and absorbability of the tocopherols led to higher inhibition. D-a-Tocopherol polyethylene glycol succinate [9002-96-4] was least effective due to its low absorbability; dl-a-tocopherol, d-a-tocopheryl acetate [58-95-7], and d-a-tocopheryl succinate [4345-03-3] showed increasing activity in this order. 9002-96-4 and 10191-41-0 are just another two chemicals used in this study. The data were complex due to the finding that some of the vehicles for carrying the vitamin E compds. were toxic to the neuroblastomas; polyethylene glycol [25322-68-3] was toxic, and Ephanyl [10191-41-0] and Tween 20 [9005-64-5] were most toxic. .

Influence of antioxidants on the bioactivity of amphotericin B

Influence of antioxidants on the bioactivity of amphotericin B. Andrews, Fred A.; Beggs, William H.; Sarosi, George A. (Gen. Med. Res. Serv., VA Hosp., Minneapolis, Minn., USA). Antimicrob. Agents Chemother., 11(4), 615-18 (English) 1977. CODEN: AMACCQ. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 3 Four antioxidants, propyl gallate [121-79-9], butylated hydroxyanisole [25013-16-5], butylated hydroxytoluene [128-37-0], and D-.alpha.-tocopherol acid succinate [4345-03-3] were found to stabilize Fungizone (smphotericin B)(I) [1397-89-3] and to prolong its antifungal activity against Candida albicans. Although each of the antioxidants was effective, propyl gallate and butylated hydroxyanisole were better than butylated hydroxytoluene and D-.alpha.-tocopherol acid succinate. None of the antioxidants alone adversely affected normal cell growth. It is suggested that I instability is due to lability of the carbon-carbon double bonds of the polyene moiety toward autoxidn. By protecting the drug mol. with an antioxidant, it is possible to lower the quantity of I necessary to obtain antifungal effects.