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CAS No.: | 438-41-5 |
---|---|
Name: | CHLORDIAZEPOXIDE HYDROCHLORIDE |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C16H14 Cl N3 O . Cl H |
Molecular Weight: | 336.221 |
Synonyms: | 3H-1,4-Benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl-, 4-oxide, monohydrochloride (9CI);3H-1,4-Benzodiazepine, 7-chloro-2-(methylamino)-5-phenyl-, 4-oxide,monohydrochloride (6CI,8CI);7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine-4-oxide hydrochloride;A-Poxide; Ansiacal; Benzodiapin; Cebrum; Chlordiazepoxide hydrochloride;Chlordiazepoxide monohydrochloride; Chlorodiazepoxide hydrochloride; Contol;Corax; Disarim; Equibral; Labican; Lentotran; Librium; Librium hydrochloride;Methaminodiazepoxide hydrochloride; NSC 115748; OCM; Psichial; Psicoterina; Reliberan;Ro 5-0690; SK-Lygen; Seren Vita; Viansin |
EINECS: | 207-117-8 |
Density: | g/cm3 |
Melting Point: | 212 - 218 C |
Boiling Point: | 451°Cat760mmHg |
Flash Point: | 226.6°C |
Solubility: |
slight
Stability
Toxicology
|
Appearance: | white crystalline powder |
Hazard Symbols: | |
Risk Codes: | 22-62-63-68 |
Safety: | Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Human systemic effects: ataxia, distorted perceptions, hallucinations, somnolence, and surface EEG changes. Mutation data reported. A minor tranquilizer. When heated to decomposition it emits very toxic fumes of HCl and NOx. |
PSA: | 53.14000 |
LogP: | 3.53800 |
Product Name: Methaminodiazepoxide hydrochloride (CAS NO.438-41-5)
Molecular Formula: C16H15Cl2N3O
Molecular Weight: 336.22g/mol
Mol File: 438-41-5.mol
Einecs: 207-117-8
Appearance: White crystalline powder
Boiling point: 566.6 °C at 760 mmHg
Flash Point: 296.5 °C
Water Solubility: Slight
Stability: Stable. Incompatible with strong oxidizing agents.
Enthalpy of Vaporization: 86.66 kJ/mol
Vapour Pressure: 3.78E-13 mmHg at 25°C
H-Bond Donor: 2
H-Bond Acceptor: 4
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | 1gm/kg (1000mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 71, 1973. | |
man | TDLo | oral | 39mg/kg/30D-I (39mg/kg) | BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: ATAXIA | Clinical Toxicology. Vol. 2, Pg. 5, 1969. |
mouse | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | Journal of Medicinal Chemistry. Vol. 14, Pg. 1106, 1971. | |
mouse | LD50 | intravenous | 95mg/kg (95mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 163, 1960. |
mouse | LD50 | oral | 530mg/kg (530mg/kg) | "Benzodinzenines," Garattini, S., et al., New York, Raven Press, 1973Vol. -, Pg. 39, 1973. | |
mouse | LD50 | parenteral | 700mg/kg (700mg/kg) | United States Patent Document. Vol. #4371536, | |
mouse | LD50 | subcutaneous | 530mg/kg (530mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 159, 1972. | |
quail | LD50 | oral | 1gm/kg (1000mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
rabbit | LD50 | intravenous | 36mg/kg (36mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: REGIDITY BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | International Journal of Neuropharmacology. Vol. 5, Pg. 305, 1966. |
rabbit | LD50 | oral | 590mg/kg (590mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 178, Pg. 216, 1969. |
rat | LD50 | intraperitoneal | 276mg/kg (276mg/kg) | Toxicology and Applied Pharmacology. Vol. 16, Pg. 556, 1970. | |
rat | LD50 | intravenous | 165mg/kg (165mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 159, 1972. | |
rat | LD50 | oral | 537mg/kg (537mg/kg) | Toxicology and Applied Pharmacology. Vol. 16, Pg. 556, 1970. | |
rat | LD50 | subcutaneous | 800mg/kg (800mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 71, 1973. | |
women | TDLo | oral | 8400ug/kg/2W- (8.4mg/kg) | BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Clinical Toxicology. Vol. 2, Pg. 5, 1969. |
EPA Genetic Toxicology Program.
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Human systemic effects: ataxia, distorted perceptions, hallucinations, somnolence, and surface EEG changes. Mutation data reported. A minor tranquilizer. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Safety Information of Methaminodiazepoxide hydrochloride (CAS NO.438-41-5):
Hazard Codes: Xn
Risk Statements: 22-62-63-68
22: Harmful if swallowed
62: Possible risk of impaired fertility
63: Possible risk of harm to the unborn child
68: Possible risk of irreversible effects
Safety Statements: 22-36/37
22: Do not breathe dust
36: Wear suitable protective clothing
37: Wear suitable gloves
Methaminodiazepoxide hydrochloride ,its CAS NO. is 438-41-5,the synonyms is 3H-1,4-benzodiazepin-2-amine,7-chloro-n-methyl-5-phenyl-,4-oxide,monohydro ; 3H-1,4-benzodiazepine,7-chloro-2-methylamino-5-phenyl-,4-oxide,monohydrochlo ; Ansiacal;a-poxide ; Benzodiapin ; Calmoden ; Cebrum ; Chlordiazachel .