Products Categories
CAS No.: | 438-60-8 |
---|---|
Name: | PROTRIPTYLINE |
Molecular Structure: | |
Formula: | C19H21 N |
Molecular Weight: | 263.382 |
Synonyms: | 5H-Dibenzo[a,d]cycloheptene-5-propylamine,N-methyl- (7CI,8CI); 5-(3-Methylaminopropyl)-5H-dibenzo[a,d]cycloheptene;7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene; Amimetilina; MK 240;N-3-(5H-Dibenzo[a,d]cyclohepten-5-yl)propyl-N-methylamine;N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine; Protriptyline;Protryptyline; Triptil |
EINECS: | 207-119-9 |
Density: | 1.026 g/cm3 |
Boiling Point: | 407.7 °C at 760 mmHg |
Flash Point: | 198.3 °C |
PSA: | 12.03000 |
LogP: | 4.69280 |
Chemistry informtion about N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine (CAS NO.438-60-8) is:
Synonyms: Protriptyline ; 3-(5h-Dibenzo[A,D]Cyclohepten-5-Yl)-N-Methyl-1-Propanamine ; 5-(3-Methylaminopropyl)-5h-Dibenzo[A,D]Cycloheptene ; 5h-Dibenzo[A,D]Cycloheptene-5-Propanamine, N-Methyl- ; 5h-Dibenzo[A,D]Cycloheptene-5-Propylamine, N-Methyl- ; 7-(3-Methylaminopropyl)-1,2:5,6-Dibenzocycloheptatriene ; Amimetilina ; N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine
MF: C19H21N
MW: 263.38
EINECS: 207-119-9
Density: 1.026 g/cm3
Flash Point: 198.3 °C Boiling Point: 407.7 °C at 760 mmHg
Vapour Pressure: 7.41E-07 mmHg at 25°C
Enthalpy of Vaporization: 65.96 kJ/mol
Following is the molecular structure of N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine (CAS NO.438-60-8) is:
N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine (CAS NO.438-60-8) including protriptyline are also used to reduce the incidence of recurring headaches such as migraine, and for other types of chronic pain. This drug can also be used for sleep apnea treatment along with a carbonic anhydrase inhibitor.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 67mg/kg (67mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
mouse | LD50 | intravenous | 30mg/kg (30mg/kg) | behavioral: changes in motor activity (specific assay) | Journal of Medicinal Chemistry. Vol. 17, Pg. 65, 1974. |
mouse | LD50 | oral | 269mg/kg (269mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
mouse | LD50 | subcutaneous | 192mg/kg (192mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
rabbit | LD50 | intravenous | 8200mg/kg (8200mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
rabbit | LD50 | oral | 310mg/kg (310mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
rat | LD50 | intraperitoneal | 42mg/kg (42mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
rat | LD50 | oral | 240mg/kg (240mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. |
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine (CAS NO.438-60-8) (Vivactil) is a tricyclic antidepressant (TCA), specifically a secondary amine, indicated for depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, and it is sometimes used in narcolepsy to achieve a wakefulness-promoting effect.[citation needed] (the other TCAs tend to be sedating and therefore are often taken in the evening).