Reference

Photosensitization by drugs

Photosensitization by drugs. Moore, Douglas E. (Dep. Pharm., Univ. Sydney, Sydney, Aust.). J. Pharm. Sci., 66(9), 1282-4 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 22 UV irradn. (365 nm) of air-satd. methanol solns. of 20 drugs absorbing in the 300-400-nm region gave rise to oxygen uptake, as detd. with a polarog. oxygen electrode. The drugs were tested for photosensitizing capability by either a Type I (free radical) or a Type II (singlet mol. oxygen) mechanism. This testing was done by the inclusion of either acrylamide or 2,5-dimethylfuran in the irradiated drug soln., with observation of the subsequent polymn. or oxidn., resp. Phenothiazine and thiazide derivs. appear capable of photosensitization by both mechanisms; promethazine-HCl [58-33-3], trifluoperazine-HCl [440-17-5], and furosemide [54-31-9] show relatively high reactivity. Diazepam [439-14-5] (weak), hexachlorophene [70-30-4], aminacrine-HCl [134-50-9], pyrilamine maleate [59-33-6], tetracycline-HCl [64-75-5], demeclocycline-HCl [64-73-3], quinine-HCl [7549-43-1], and anthracene [120-12-7] (strong) react only by a Type II mechanism, with a photosensitizing efficiency increasing in the order given. A correlation appears to exist with reports of in vivo photosensitivity.

Microcrystalloscopic identification of some piperazine derivatives of phenothiazine

Microcrystalloscopic identification of some piperazine derivatives of phenothiazine. Popova-Baltova, E.; Popova, M. (I. P. Pavlov Med. Fac., Plovdiv, Bulg.). Farmatsiya (Moscow), 26(3), 63-4 (Russian) 1977. CODEN: FRMTAL. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Taxilan (I) [84-97-9] was extd. from tablets or acidified urine with CHCl3 and reacted with 5% H2PdCl6, KI3, 5% Zn(IO3)2 soln., ZnClI, or 0.5% H2PtCl6 soln. to form microcrystals. These reactions were sensitive to 2-10 .mu.g I. Stelazine [440-17-5] was similarly detected by microcrystn. with K nitritodiamminecobaltate, with a sensitivity of 25 mg. Except for the crystn. with ZnClI, these reactions were specific for I and stelazine, other phenothiazine derivs., alkaloids, and barbiturates showing no microcrystn. in amts. .ltoreq.100 .mu.g.