Detail of "4412-16-2"

Reference

Carcinostatic pharmaceuticals containing fatty acids or their esters

Carcinostatic pharmaceuticals containing fatty acids or their esters. (Iwamura, Juichi, Japan). Jpn.In this study， 2482-39-5 and 64192-83-2 are also used. Kokai Tokkyo Koho JP 58213716 A2 12 Dec 1983 Showa, 6 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K031-19; A61K031-20; A61K031-22; A61K031-23. APPLICATION: JP 82-96636 5 Jun 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 Carcinostatic pharmaceuticals contain the fatty acids or their esters Me(CH2)mACO2R [A = CH:CR1, CH2CH(OH) or CH(OH)CHR1 (R, R1 = H or C<10 alkyl; m = 1-13] as active ingredient. Thus, i.p. administration of 2-dodecenoic acid [4412-16-2] (2.5 mg/animal/day) in 0.1% CM-cellulose to mice with exptl. inoculated Ehrlich ascites carcinoma for 4 days prolonged the survival time from 12 days in untreated controls to 21 days. Soft capsules were prepd. contg. 2-dodecenoic acid 50 and linolic acid 50 parts. Each capsule contained 50 mg 2-dodecenoic acid. .