CAS No.443-88-9,Benzene,2-fluoro-1,3-dimethyl- Suppliers,MSDS download

Detail of "443-88-9"

MSDS Download

CAS Number:

443-88-9

Name:

Benzene,2-fluoro-1,3-dimethyl-

Superlist Name:

2,6-Dimethylfluorobenzene

Molecular Structure:

Formula:

C₈H₉F

Molecular Weight:

124.16

Synonyms:

2-Fluoro-1,3-dimethylbenzene;2-Fluoro-1,3-xylene;2-Fluoro-m-xylene;3-Methyl-2-fluorotoluene;2,6-Dimethylfluorobenzene;1-Fluoro-2,6-dimethylbenzene;m-Xylene,2-fluoro- (6CI,7CI,8CI);1,3-Dimethyl-2-fluorobenzene;

EINECS:

207-144-5

Density:

0.983 g/cm³

Boiling Point:

143.9 °C at 760 mmHg

Flash Point:

30.4 °C

Hazard Symbols:

Risk Codes:

Safety:

16 Details

Transport Information:

UN 1993

Reference

Mechanism of aromatic hydroxylation in a copper monooxygenase model system: Mechanism of aromatic hydroxylation in a copper monooxygenase model system. 1,2-Methyl migrations and the NIH shift in copper chemistry. Nasir, M. Sarwar; Cohen, Brett I.; Karlin, Kenneth D. (Dep. Chem., Johns Hopkins Univ., Baltimore, MD 21218, USA). J. Am. Chem. Soc., 114(7), 2482-94 (English) 1992. CODEN: JACSAT. ISSN: 0002-7863. DOCUMENT TYPE: Journal CA Section: 7 (Enzymes) Section cross-reference(s): 78 The NIH shift mechanism appears to be operative in a copper monooxygenase model system involving dicopper ion complex mediated O2 hydroxylation of an arene substrate. Previous studies have shown that when a dicopper(I) complex contg. two tridentate PY2 units (PY2 = bis[2-(2-pyridyl)ethyl]amine) which are linked by a m-xylyl group (XYL-H), i.e., [Cu2(XYL-H)]2+, is reacted with dioxygen, a Cu2O2 intermediate forms and hydroxylation in the intervening 2-xylyl position occurs. Here, corresponding reactions of 2-Me substituted analogs [Cu2(Me2XYL-CH3)]2+ and [Cu2(XYL-CH3)]2+ are described in detail. Oxygenation of these causes xylyl hydroxylation reactions producing new phenol products, with concomitant 1,2-migration of the Me group, loss of one PY2 ligand arm, and formaldehyde formation. Manometric O2 uptake expts. and an 18O2 labeling study confirm that the stoichiometry of these reactions are consistent with that obsd. for monooxygenases. A reaction carried out using a dinucleating ligand which has been deuterated in benzylic positions confirms that the CH2O product is derived from this carbon atom, a result also consistent with migration of the 2-Me group. A small yield of methylbis[2-(2-pyridyl)ethyl]amine (MePY2) is consistently obtained, and expts. suggest this may be derived from the redn. of an intermediate imminium salt {CH2:N[CH2CH2PY]2} + (PY = 2-pyridyl). The hydroxylation induced 1,2-Me migrations obsd. here are reminiscent of the NIH shift reactions previously obsd. only in iron hydroxylases and suggest that the copper ion mediated reactions proceed by the electrophilic attack of a Cu2O2 intermediate upon the proximate arom. substrate.In this experiment, several chemicals are used like 139016-43-6 and 443-88-9 A detailed mechanism is proposed and discussed in terms of the known O2 reactivity and structure of these dinuclear copper complexes. The biol. relevance and significance of this monooxygenase model system is also discussed. .

Detail of "443-88-9"

Benzene,2-fluoro-1,3-dimethyl-

Famous Chemical Enterprises

Related products

Other Products

Supplier Location

Business Type

Certificates

CAS No.443-88-9 2,6-dimethylfluorobenzene

CAS No.443-88-9 2,6-Dimethylfluorobenzene

CAS No.443-88-9 2,6-Dimethylfluorobenzene

CAS No.443-88-9 2,6-Dimethylfluorobenzene

CAS No.443-88-9 2,6-Dimethylfluorobenzene

CAS No.443-88-9 2,6-Dimethylfluorobenzene

CAS No.443-88-9 2,6-Dimethylfluorobenzene

CAS No.443-88-9 2,6-Dimethylfluorobenzene

CAS No.443-88-9 2,6-Dimethylfluorobenzene

CAS No.443-88-9 2,6-Dimethylfluorobenzene

CAS No.443-88-9 2,6-Dimethylfluorobenzene

CAS No.443-88-9 2,6-Dimethylfluorobenzene

CAS No.443-88-9 2,6-Dimethylfluorobenzene

Reference