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Detail of "4430-77-7"

  • CAS Number:
  • 4430-77-7
  • Name:

  • Pyrido[2,3-d]pyridazine-5,8-dione,6,7-dihydro-

  • Superlist Name:
  • Pyrido[2,3-d]pyridazine-5,8-diol
  • Molecular Structure:
  • Formula:
  • C7H5N3O2
  • Molecular Weight:
  • 163.14
  • Synonyms:
  • 2,3-Pyridinedicarboxylicacid, cyclic hydrazide;6,7-Diaza-5,8-dioxo-5,6,7,8-tetrahydroquinoline;6,7-Dihydropyrido[2,3-d]pyridazine-5,8-dione;NSC 131213;NSC 131226;NSC 3846;Pyrido[2,3-d]pyridazine-5,8-diol;Quinolinic hydrazide;
  • Density:
  • 1.424 g/cm3
  • Boiling Point:
  • 563.1 °C at 760 mmHg
  • Flash Point:
  • 294.4 °C
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CAS No.4430-77-7 Pyrido[2,3-d]pyridazine-5,8-diol

Gladys Preliminary evaluation of the cytostatic activity of some hydrazides and their derivatives Preliminary evaluation of the cytostatic activity of some hydrazides and their derivatives. Grzycka, Kazimiera (Inst. Anal. Technol. Farm., Akad. Med., Lublin, Pol.). Ann. Univ. Ma

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CAS No.4430-77-7 Pyrido[2,3-d]pyridazine-5,8-diol

Supplier:Hangzhou Imaginechem Co., Ltd [ China (Mainland)]

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Reference

Preliminary evaluation of the cytostatic activity of some hydrazides and their derivatives
Preliminary evaluation of the cytostatic activity of some hydrazides and their derivatives. Grzycka, Kazimiera (Inst. Anal. Technol. Farm., Akad. Med., Lublin, Pol.). Ann. Univ. Mariae Curie-Sklodowska, Sect. D, 32, 135-8 (Polish) 1977. CODEN: AUMKAS. ISSN: 0066-2240. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) The Triticum test of D. G. Constantinescu et al. (1963) was used to assess the cytostatic activity of 6 hydrazides and their derivs. Maleic hydrazide (I) [123-33-1] was the most active, causing 62-100% change in mitosis at an initial concn. of 0.025%. Its smallest active concn. (CMA) was 0.0069%. Quinolinic hydrazide [4430-77-7] was less active, with a CMA of 0.0268%. 3-Aminophthalic hydrazide [521-31-3], 1-N-piperidinomethyl-3-chloro-6-pyridazinone [14628-39-8], 8-hydroxy-6-N-pyrazinomethyl-1-azaphthalazone [67323-50-6], and 5-(pyridinioacetamido)dihydrophthalazine-1,4-dione chloride [54569-66-3] were the least active, inducing only 6.2-56.0% change in mitosis at 0.1%.
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