Products Categories
CAS No.: | 443642-29-3 |
---|---|
Name: | Lamevudine |
Article Data: | 11 |
Molecular Structure: | |
Formula: | C12H16 N4 O4 |
Molecular Weight: | 280.283 |
Synonyms: | 7-Deaza-2'-C-methyladenosine;MK 0608 |
Density: | 1.75±0.1 g/cm3(Predicted) |
Melting Point: | 222 °C(Solv: methanol (67-56-1); acetonitrile (75-05-8)) |
Boiling Point: | 620.7±55.0 °C(Predicted) |
PSA: | 126.65000 |
LogP: | -0.40370 |
4-chloro-7-[2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine
7-deaza-2'-C-methyl-adenosine
Conditions | Yield |
---|---|
With ammonia at -78 - 85℃; for 24h; | 97% |
With ammonia at -78 - 85℃; for 24h; | 97% |
With ammonia In methanol at 85℃; for 14h; | 56% |
4-phthalimido-7-[3',5'-di-O-(4-methylbenzoyl)-2'-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine
7-deaza-2'-C-methyl-adenosine
Conditions | Yield |
---|---|
With N-butylamine In methanol; toluene at 64℃; | 25 g |
4-amino-7H-pyrrolo[2,3-d]pyrimidine-2-sulfinic acid
7-deaza-2'-C-methyl-adenosine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 84 percent / sulfuric acid / 5.5 h / 20 - 75 °C 2: 85.6 percent / N,N-dimethylacetamide; N,N-diisopropylethylamine 3: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 4: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme |
7-deaza-2'-C-methyl-adenosine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: 10.81 kg / Triton X-405; KOH / toluene; H2O / 20 h / Heating 2.1: 9.02 kg / aq. sulfuric acid / toluene; acetonitrile / 19 °C 3.1: pyridine / acetonitrile / 12 h / 50 - 55 °C 4.1: aq. HBF4 / acetonitrile / 2 h / 50 - 55 °C 5.1: periodic acid / H2O / 0.5 h / 0 - 5 °C 5.2: diisopropylamine; aq. isopropyl acetate; aq. HCl / methanol / 0 °C 5.3: 4.03 kg / isopropyl acetate; H2 / Pd/C / 24 h / 50 °C / 2327.17 Torr 6.1: 93 percent / MsCl; Et3N / CH2Cl2 / 1.67 h / 30 °C 7.1: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 8.1: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme |
2-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)isoindoline-1,3-dione
7-deaza-2'-C-methyl-adenosine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 2: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme |
7-deaza-2'-C-methyl-adenosine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 9.02 kg / aq. sulfuric acid / toluene; acetonitrile / 19 °C 2.1: pyridine / acetonitrile / 12 h / 50 - 55 °C 3.1: aq. HBF4 / acetonitrile / 2 h / 50 - 55 °C 4.1: periodic acid / H2O / 0.5 h / 0 - 5 °C 4.2: diisopropylamine; aq. isopropyl acetate; aq. HCl / methanol / 0 °C 4.3: 4.03 kg / isopropyl acetate; H2 / Pd/C / 24 h / 50 °C / 2327.17 Torr 5.1: 93 percent / MsCl; Et3N / CH2Cl2 / 1.67 h / 30 °C 6.1: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 7.1: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme |
1,2-anhydro-2-C-methyl-3,5-di-O-(4-methylbenzoyl)-α-D-ribofuranose
7-deaza-2'-C-methyl-adenosine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 2: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme |
7-deaza-2'-C-methyl-adenosine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 85.6 percent / N,N-dimethylacetamide; N,N-diisopropylethylamine 2: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 3: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme |
2-C-methyl-3,5-di-O-(4-methylbenzoyl)-D-ribofuranose
7-deaza-2'-C-methyl-adenosine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 93 percent / MsCl; Et3N / CH2Cl2 / 1.67 h / 30 °C 2: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 3: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme |
7-deaza-2'-C-methyl-adenosine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: periodic acid / H2O / 0.5 h / 0 - 5 °C 1.2: diisopropylamine; aq. isopropyl acetate; aq. HCl / methanol / 0 °C 1.3: 4.03 kg / isopropyl acetate; H2 / Pd/C / 24 h / 50 °C / 2327.17 Torr 2.1: 93 percent / MsCl; Et3N / CH2Cl2 / 1.67 h / 30 °C 3.1: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 4.1: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme |