Reference

Antitumor formulations containing flavonoids

Antitumor formulations containing flavonoids. (Institute of Physical and Chemical Research, Japan). Jpn. Kokai Tokkyo Koho JP 59046217 A2 15 Mar 1984 Showa, 8 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K031-35. ICA: C07D311-30; C07D311-32; C07D311-36. APPLICATION: JP 82-157103 9 Sep 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 Antitumor formulations contain flavonoids or isoflavonoids (I and II), where R1, R2, R3, and R4 = H, OH, or OMe; R5 and R6 = H, OH, OMe, or 3,4,5-R7R8R9C6H2 (R7, R8, and R9 = H, OH, or OMe). Thus, 10 mg genistein (I, R1 = R3 = OH, R2 = R4 = R5 = H, R6 = 4-HOC6H4) [446-72-0] was mixed with 5 g glucose powder and sealed in a vial with an inert gas. Immediately before its use, the mixt. was dissolved in EtOH and combined with 100 mL 0.85% saline to give an i.v. injection soln. The antitumor activity against mouse erythroid leukemia cells was demonstrated in vitro.

Antioxidative stability of tempeh and liberation of isoflavones by fermentation

Antioxidative stability of tempeh and liberation of isoflavones by fermentation. Murakami, Hiroshi; Asakawa, Tomomi; Terao, Junji; Matsushita, Setsuro (Res. Inst. Food Sci., Kyoto Univ., Uji 611, Japan). Agric. Biol. Chem., 48(12), 2971-5 (English) 1984. CODEN: ABCHA6. ISSN: 0002-1369. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) Isoflavones and their glucosides in tempeh were analyzed by HPLC, and the liberation of isoflavones from glucosides was obsd. during fermn. The main isoflavones responsible for the antioxidative activity in tempeh were daidzein [486-66-8] and genistein [446-72-0].