Detail of "448-97-5"
- CAS Number:
- 448-97-5
- Name:
[1,1'-Biphenyl]-4,4'-diamine,3,3'-difluoro-
- Molecular Structure:
![Molecular Structure of 448-97-5 ([1,1'-Biphenyl]-4,4'-diamine,3,3'-difluoro-)](http://www.lookchem.com/300w/2010/0621/448-97-5.jpg)
- Formula:
- C12H10 F2 N2
- Molecular Weight:
- 0
- Synonyms:
- Benzidine,3,3'-difluoro- (6CI,8CI)
- Density:
- 1.313g/cm3
- Boiling Point:
- 335.8°Cat760mmHg
- Flash Point:
- 152.2°C
[1,1'-Biphenyl]-4,4'-diamine,3,3'-difluoro-
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Reference
- Synthesis and mutagenicity of 3,3'-dihalogenated benzidines
- Synthesis and mutagenicity of 3,3'-dihalogenated benzidines. Savard, Shaunalea; Josephy, P. David (Dep. Chem. Biochem., Univ. Guelph, Guelph, ON N1G 2W1, Can.). Carcinogenesis (London), 7(7), 1239-41 (English) 1986.There are some reagents with their cas registry numbers 92-87-5 and 34237-98-4 are used in this study. CODEN: CRNGDP. ISSN: 0143-3334. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 25 3,3'-Difluorobenzidine (F2Bz)(I) [448-97-5] and 3,3'-dibromobenzidine (Br2Bz) [34237-98-4] were synthesized and compared with 3,3'-dichlorobenzidine (Cl2Bz) [91-94-1] for ability to revert Salmonella typhimurium. The relative mutagenicities in all systems tested are Cl2Bz u Br2Bz > F2Bz > benzidine [92-87-5]. F2Bz, Cl2Bz, and Br2Bz are direct-acting mutagens towards S. typhimurium strain TA98. The acetylase [9012-30-0]-deficient deriv. TA98/1,8-DNP6 displays no resistance to induction of mutagenesis by these compds., in the absence of mammalian activation. With addn. of hamster hepatic S-9 activation the mutagenicity of these compds. increases greatly. TA98/1,8-DNP6 shows some resistance to this mutagenicity. Multiple mechanisms must exist for the genotoxicity of 3,3'-dihalogenated benzidines. .