CAS No.450-88-4,2-Bromo-5-fluoroanisole Suppliers

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Basic Information

Molecular Structure:
CAS No.:	450-88-4
Name:	2-Bromo-5-fluoroanisole
Article Data:	34

Formula:	C₇H₆BrFO
Molecular Weight:	205.026
Synonyms:	1-Bromo-4-fluoro-2-methoxybenzene;2-Bromo-5-fluoroanisole;Anisole,6-bromo-3-fluoro- (8CI);
Density:	1.531 g/cm³
Boiling Point:	187.9 °C at 760 mmHg
Flash Point:	80.2 °C
Hazard Symbols:	Xn
Risk Codes:	36/37/38-36-22
Safety:	26-36/37/39
PSA:	9.23000
LogP:	2.59680

Synthetic route

: 77-78-1
dimethyl sulfate

: 147460-41-1
2-bromo-5-fluorophenol

: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 2h;	100%
With potassium carbonate In acetone at 60℃; for 2h;	100%
With potassium carbonate In acetone at 60℃; for 2h;	100%

: 450-91-9
4-fluoro-2-methoxyaniline

: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

Conditions

Conditions	Yield
Stage #1: 4-fluoro-2-methoxyaniline With sodium nitrite In water at -5 - 0℃; Stage #2: With hydrogen bromide; copper(I) bromide In water at 105℃;	93%
Diazotization;

: 147460-41-1
2-bromo-5-fluorophenol

: 74-88-4
methyl iodide

: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;	93%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 3h;
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 3h;

: 348-57-2
2,4-difluorobromobenzene

: 865-33-8
potassium methanolate

: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

Conditions

Conditions	Yield
In tetrahydrofuran at 65 - 68℃; for 5h;	93%
In tetrahydrofuran at 65 - 68℃; for 5h;	93%
In tetrahydrofuran at 65℃; for 4h;	90%

: 395-82-4
4-fluoro-2-methoxy-benzoic acid

: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

Conditions

Conditions	Yield
With potassium phosphate; tetrabuthylammonium tribromide In acetonitrile at 100℃; for 16h;	75%

: 67-56-1
methanol

: 348-57-2
2,4-difluorobromobenzene

: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

Conditions

Conditions	Yield
Stage #1: methanol With sodium hydride In tetrahydrofuran at 0℃; for 15h; Stage #2: 2,4-difluorobromobenzene In tetrahydrofuran at 20℃; for 17h; Further stages.;	42%

: 348-57-2
2,4-difluorobromobenzene

: 865-33-8
potassium methanolate

A: 17715-69-4
1-Bromo-2,4-dimethoxybenzene

B: 458-50-4
1-bromo-2-fluoro-4-methoxybenzene

C: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

Conditions

Conditions	Yield
In tetrahydrofuran at 65 - 68℃; for 22h; Inert atmosphere; regioselective reaction;	A 9% B n/a C n/a

...Expand

: 456-49-5
1-fluoro-3-methoxybenzene

A: 458-50-4
1-bromo-2-fluoro-4-methoxybenzene

B: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

Conditions

Conditions	Yield
With bromine; tetramethylammonium bromide In liquid sulphur dioxide at -23℃; Product distribution; Rate constant;
With bromine; iron In chloroform at -60℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 2591-86-8
N-Formylpiperidine

: 456-49-5
1-fluoro-3-methoxybenzene

A: 331-64-6
2-fluoro-4-methoxy-benzaldehyde

B: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

C: 450-83-9
2-methoxy-4-fluorobenzaldehyde

Conditions

Conditions	Yield
Yield given. Multistep reaction;

...Expand

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: iron; aqueous acetic acid 2: Diazotization View Scheme
Multi-step reaction with 2 steps 1.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 30 - 35 °C / 3750.38 - 7500.75 Torr / Autoclave; Inert atmosphere 2.1: sodium nitrite / water / -5 - 0 °C 2.2: 105 °C View Scheme

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Chemistry

IUPAC Name: 1-bromo-4-fluoro-2-methoxybenzene
Molecular Formula: C₇H₆BrFO
Molecular Weight: 205.02g/mol
Density: 1.531g/cm³
Boiling Point: 187.9 °C at 760 mmHg
Flash Point: 80.2 °C
Freely Rotating Bonds: 1
Polar Surface Area: 9.23 Å²
Index of Refraction: 1.518
Molar Refractivity: 40.61 cm³
Molar Volume: 133.8 cm³
Polarizability: 16.1 ×10^-24 cm³
Surface Tension: 33.3 dyne/cm
Enthalpy of Vaporization: 40.67 kJ/mol
Vapour Pressure: 0.849 mmHg at 25°C
The synonyms of 2-Bromo-5-fluoroanisole (450-88-4) are Buttpark 87\07-62 ; 2-Bromo-5-fluoroanisole ; 1-Bromo-4-fluoro-2-methoxybenzene ; 2-Bromo-5-fluoroanisole98+% .Product categories of 2-Bromo-5-fluoroanisole (450-88-4) is Anisole .The molecular structure of 2-Bromo-5-fluoroanisole (450-88-4) is .

Uses

2-Bromo-5-fluoroanisole (450-88-4) can be used in organic synthesis.

Safety Profile

Hazard Symbols: Xn
Risk Statements: 36/37/38-36-22
22: Harmful if swallowed
36: Irritating to the eyes
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements： 26-36/37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection