Detail of "4510-16-1"

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CAS Number:
4510-16-1
Name:
Prosta-5,13-dien-1-oicacid, 9,11,15-trihydroxy-, (5Z,9β,11α,13E,15S)-
Molecular Structure:
Formula:
C₂₀H₃₄O₅
Molecular Weight:
354.481
Synonyms:
5-Heptenoicacid, 7-[3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-, stereoisomer (8CI);7-[3a,5b-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoicacid;9b,11a-PGF2a;PGF2b;Prostaglandin F2b;
Density:
1.153 g/cm³
Melting Point:
105-106°C
Boiling Point:
531 °C at 760 mmHg
Flash Point:
289 °C

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Cardiovascular actions of prostaglandins F2: Cardiovascular actions of prostaglandins F2.alpha.; 15-me-F2.alpha.; F1.alpha.; F2.beta. and F1.beta. in the cat. Koss, Michael C. (Coll. Med., Univ. Oklahoma, Oklahoma City, Okla., USA). Prostaglandins, 12(6), 997-1004 (English) 1976.Some commonly used reagents like 35700-23-3 and 10164-73-5 are used in this experiment. CODEN: PRGLBA. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Prostaglandin F2.alpha. (I) [551-11-1] (5 .mu.g/kg, i.v.) increased pulmonary arterial pressure and decreased systemic arterial pressure and reflex bradycardia in the anesthetized cat. The same dose of the 15-methyl-PGF2.alpha. [35700-23-3] produced the same triad of effects but of greater magnitude and duration. Although prostaglandins F1.alpha. [745-62-0], F2.beta. [4510-16-1], and F1.beta. [10164-73-5] also caused the same cardiovascular effects as I, there was a decrease in potency for all parameters measured, with I > PGF1.alpha. > PGF2.beta. > PGF1.beta.. When compared to the actions of I in producing an increase in pulmonary arterial pressure, prostaglandins F1.alpha., F2.beta., and F1.beta. were less potent by .apprx.10-, 100-, and 1000-fold, resp. .

Preparation of reversed-phase TL plates by "in situ" chemical reaction with alkylchlorosilanes: separation of prostaglandins and thromboxane: Preparation of reversed-phase TL plates by "in situ" chemical reaction with alkylchlorosilanes: separation of prostaglandins and thromboxane. Beneytout, J. L.; Greuet, D.; Tixier, M.; Rigaud, M. (Lab. Chim. Biol., Fac. Med. Pharm. Limoges, Limoges 87032, Fr.). HRC CC, J. High Resolut. Chromatogr. Chromatogr. Commun., 6(9), 516-18 (English) 1983. CODEN: HCJCDB. ISSN: 0344-7138. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Silicone-bonded TLC plates were prepd. from alkylchlorosilanes and polydimethylsiloxanes of varying chain length and from combinations of these products for sepn. of prostaglandins and thromboxanes. The mobile phase used was hexane: Me formate: di-Et ether: acetic acid (: vol./vol.). Initial treatment of TLC plates with dimethylchlorosilane [1066-35-9] followed by subsequent reaction with polymethylsiloxanes (50, 80, and 200 cSt) was more effective than existing procedures for sepn. of PGD2 [41598-07-6], PGE2 [363-24-6], PGF2a [551-11-1], PGF2b [4510-16-1], and TXB2 [54397-85-2]. The silicone layer did not interfere with elution of the sepd. prostaglandins or TXB2.