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Detail of > 452-35-7

  • CAS Number:
  • 452-35-7
  • Name:
  • 6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE

  • Formula:
  • C9H10N2O3S2
  • Molecular Structure:
  • Synonyms:
  • 6-ETHOXYZOLAMIDE;6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE;ETHOXZOLAMIDE;2-Benzothiazolesulfonamide, 6-ethoxy-;6-Ethoxy-1,3-benzothiazole-2-sulfonamide;6-ethoxy-2-benzothiazolesulfonamid;6-Ethoxybenzothiazole-2-sulfonamide;Cardrase
  • Molecular Weight:
  • 258.33
  • Density:
  • 1.47g/cm3
  • Melting Point:
  • 190-193 °C(lit.)
  • Boiling Point:
  • 464.9°Cat760mmHg
  • Flash Point:
  • 235°C
  • Hazard Symbols:
  • Risk Codes:
  • 36/37/38
  • Safety:
  • Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of SOx and NOx.Details
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Reference

Gastric cytoprotection with heterocyclic sulfonamides
Gastric cytoprotection with heterocyclic sulfonamides. Robert, Andre (Upjohn Co. , USA). 9001-03-0 and 53336-84-8 are also occured in this study. U.S. US 4424227 A 3 Jan 1984, 4 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-425. NCL: 424270000. APPLICATION: US 82-375144 5 May 1982. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Gastrointestinal inflammatory disease can be prevented by the administration of thiazole sulfonamides known to be carbonic anhydrase [9001-03-0] inhibitors. Oral administration of N-methyl-2-benzothiazolesulfonamide [66003-69-8], 5-(2-methylpropionamido)-1,3,4-thiadiazole-2-sulfonamide [53336-84-8], acetazolamide [59-66-5], or ethoxzolamide [452-35-7] (50 mg/kg) to rats decreased the no. of necrotic lesions caused by the administration of abs. EtOH. .
The effects of acetazolamide and of ethoxzolamide on gastric microcirculation in rats (histochemical study)
The effects of acetazolamide and of ethoxzolamide on gastric microcirculation in rats (histochemical study). Barbarino, Fedora; Toganel, Elvira; Brilinschi, Cornelia (Inst. Hyg. Public Health, Cluj-Napoca, Rom.). Ann. N. Y. Acad. Sci., 429(Biol. Chem. Carbonic Anhydrases), 601-3 (English) 1984. CODEN: ANYAA9. ISSN: 0077-8923. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Acetazolamide [59-66-5] and ethoxzolamide [452-35-7] prevented reserpine-induced gastric ulceration. The 2 drugs enhanced gastric microcirculation, preserved epithelial glycoproteins, and caused morphol. and functional changes in other mucosal cells.

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