Reference

Multicomponent Reactions to Form Heterocycles by Microwave-Assisted Continuous Flow Organic Synthesis

Bremner, W. Stacy; Organ, Michael G.Several substances are used for example 455-19-6 and 123-08-0 which are their cas registry numbers. (Department of Chemistry, York University, Toronto, ON M3J 1P3, Can.). Journal of Combinatorial Chemistry, 9(1), 14-16 (English) 2007 American Chemical Society. CODEN: JCCHFF. ISSN: 1520-4766. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 27, 45 The authors detail the use of microwave-assisted continuous flow org. synthesis (MACOS) to prep. medicinally relevant, heterocyclic compds. in a multicomponent reaction (MCR) format. E.g., the prepn. of tetrahydropyrazolo[3,4-b]quinolin-5(6H)-ones (I, R = NMe2, CN, CO2Me, Br, OH, OMe) was accomplished by reacting equimolar amts. of dimedone, 5-amino-3-methyl-1H-pyrazole, and substituted benzaldehydes 4-RC6H4CHO in an efficient, microwave-assisted method. Reaction optimization consisted of varying the capillary diam., microwave power, flow-rate, reaction concn., and solvent. .

Synthesis of p-trifluoromethylcinnamic acid

All Rights Reserved. Synthesis of p-trifluoromethylcinnamic acid. Chen, Hong-biao; Lin, Yuan-bin; Peng, Zhi-yong; Liu, Chan-juan ( College of Chemistry, Xiangtan University, Xiangtan 411105, Peop. Rep. China). Hecheng Huaxue, 14(3), 314-316 (Chinese) 2006 Hecheng Huaxue Bianjibu.Several substances with their cas registry numbers 455-19-6 and 455-14-1 may be metioned in this study. CODEN: HEHUE2. ISSN: 1005-1511. DOCUMENT TYPE: Journal CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Highly purified p-trifluoromethylcinnamic acid with the total yield of 41.4% was synthesized from p-trifluoromethylaniline by diazotization, formylation, and condensation. .