Reference

Preparation of 4-pyridinethiols without using hydrogen sulfide

Some chemicals with cas registry numbers like 16721-80-5 and 16077-77-3 are also used. Preparation of 4-pyridinethiols without using hydrogen sulfide. Mitsui, Yasutaka (Koei Chemical Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 2005008608 A2 13 Jan 2005, 6 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: C07D213-70. APPLICATION: JP 2003-177618 23 Jun 2003. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) 4-Pyridinethiols are prepd. by reaction of 4-pyridylpyridinium dihydrohalide salts with alkali metal hydrosulfides. Pyridine was treated with S and Cl at 100-120° for 30 min, treated with aq. NaHS at 105° for 1 h, and mixed with aq. NaOH to give 64.7% 4-pyridinethiol. .

Naphthoquinone antipsoriatic agents

Naphthoquinone antipsoriatic agents. Jones, Gordon H.; Young, John (Syntex (U.S.A.), Inc., USA). U.S. US 4419368 A 6 Dec 1983, 11 pp. Cont.-in-part of U.S. Ser. No. 144,479, abandoned. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-12. NCL: 424331000. APPLICATION: US 81-317645 2 Nov 1981. PRIORITY: US 78-912697 5 Jun 1978; US 80-144479 28 Apr 1980. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Section cross-reference(s): 1, 63 Antipsoriatic (no data) tetrahydroxy-1,4-naphthoquinones I [R = alkoxy, cyano, halo, R1S(O)n; R1 = (un)substituted alkyl, Ph, heteroaryl; n = 0-2] were prepd. Thus, 14.0 g chlorobenzene deriv. II (R2 = Me) was brominated with N-bromosuccinimide to give 34% II (R2 = CHBr2).There are some commonly used reagents with their cas registry numbers 89226-82-4 and 4556-23-4 in this article. This (22.8 g) was treated with AgOAc in HOAc to give II [R2 = CH(OAc)2], which was hydrolyzed to give 6.0 g II (R2 = CHO), 4.88 g of which was cyclocondensed with glyoxal bisulfite to give 3.56 g dihydroxynaphthoquinone III. Cl was passed through a suspension of 225 mg III in 50% aq. HOAc to give 214 mg I (R = 6-Cl). .