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457-60-3

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Basic Information
CAS No.: 457-60-3
Name: Neoarsphenamine
Molecular Structure:
Molecular Structure of 457-60-3 (Neoarsphenamine)
Formula: C13H14 As2 N2 O4 S . Na
Molecular Weight: 466.17
Synonyms: Methanol,[5-[(3-amino-4-hydroxyphenyl)arseno]-2-hydroxyanilino]-, 1-(hydrogensulfoxylate) (ester), monosodium salt (8CI); Sulfoxylic acid,mono[[[5-[(3-amino-4-hydroxyphenyl)diarsenyl]-2-hydroxyphenyl]amino]methyl]ester, monosodium salt (9CI); Neo-I.C.I.; Neoarsphenamine; Neosalvarsan;Novarsenobenzol; Novarsenobillon; Novarsenol; Sodium3,3'-diamino-4,4'-dihydroxyarsenobenzene-N-formaldehydesulfoxylate; Sodium3,3'-diamino-4,4'-dihydroxyarsenobenzene-N-methylene-sulfoxylate; Sodiump,p'-dihydroxy-m,m'-diaminoarsenobenzene-N-monomethanol sulfoxylate
EINECS: 207-273-7
Density: g/cm3
Boiling Point: °Cat760mmHg
Flash Point: °C
Hazard Symbols: Xn
Risk Codes: 22
Safety: Poison by intravenous and subcutaneous routes. When heated to decomposition it emits very toxic fumes of As, NOx, Na2O, and SOx. See also ARSENIC COMPOUNDS.
PSA: 137.85000
LogP: 0.94760
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Chemistry

IUPAC Name: Sodium [5-(3-amino-4-hydroxyphenyl)arsanylidenearsanyl-2-hydroxyanilino]methanesulfinate
Synonyms of Neosalvarsan (CAS NO.457-60-3): ((5-(3-Amino-4-hydroxyphenyl)arseno)-2-hydroxyanilino)methanol sulfoxylate sodium ; 3,3'-Diamino-4,4'-dihydroxyarsenobenzenemethylenesulfoxylate sodium ; Arsevan ; Arsphenamine methylenesulfoxylic acid sodium salt ; Neo-gargarol liquidum ; Sodium 3,3'-diamino-4,4'-dihydroxyarsenobenzene-N-formaldehydesulfoxylate ; Sulfoxylic acid, mono(((5-((3-amino-4-hydroxyphenyl)diarsenyl)-2-hydroxyphenyl)amino)methyl) ester, monosodium salt
CAS NO: 457-60-3
Molecular Formula: C13H13As2N2NaO4S
Molecular Weight : 466.15
Molecular Structure:  
EINECS: 207-273-7 
Appearance: Yellow powder or granules.
Water solubility: Soluble in water, insoluble in alcohol, chloroform and ether.

History

 Neosalvarsan is a synthetic chemotherapeutic that is an organoarsenic compound. They were replaced for this indication by penicillin in the 1940s, because both of these arsenicals carried considerable risk of side-effects. It became available in 1912 and superseded the more toxic and less water-soluble salvarsan as an effective treatment for syphilis.

Uses

 Neosalvarsan (CAS NO.457-60-3) is used as an effective treatment for syphilis.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intraperitoneal 75mg/kg (75mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
guinea pig LDLo subcutaneous 75mg/kg (75mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
mouse LD50 intravenous 370mg/kg (370mg/kg)   Therapie. Vol. 2, Pg. 28, 1947.
mouse LDLo intraperitoneal 75mg/kg (75mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
mouse LDLo subcutaneous 100mg/kg (100mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
rabbit LDLo intravenous 150mg/kg (150mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
rat LD50 intravenous 318mg/kg (318mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 73, Pg. 12, 1941.
rat LDLo intraperitoneal 50mg/kg (50mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
rat LDLo subcutaneous 75mg/kg (75mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.

Consensus Reports

Arsenic and its compounds are on the Community Right-To-Know List.

Safety Profile

Hazard Codes: HarmfulXn
Risk Statements: 22
R22: Neosalvarsan (CAS NO.457-60-3) is harmful if swallowed.
Safety Statements: 24/25-36
S24/25: Avoid contact with skin and eyes. 
S36: Wear suitable protective clothing.

Poison by intravenous and subcutaneous routes. When heated to decomposition it emits very toxic fumes of As, NOx, Na2O, and SOx. See also ARSENIC COMPOUNDS.

Standards and Recommendations

OSHA PEL: TWA 0.5 mg(As)m3
ACGIH TLV: BEI: 35 µ (As)/L inorganic arsenic and methylated metabolites in urine

Specification

 Neosalvarsan (CAS NO.457-60-3) is easily oxidized in the air,and  accelerate oxidation when the temperature is high .