Detail of "4572-03-6"

Reference

N-Alkylation of unsymmetric piperazines

N-Alkylation of unsymmetric piperazines. Chung, Byung Ho; Zymalkowski, Felix (Pharm. Inst., Univ. Bonn-Poppelsdorf, Bonn D-5300/1, Fed.Chemical with cas number 4572-03-6 also plays role. Rep. Ger.). Arch. Pharm. (Weinheim, Ger.), 317(4), 323-9 (German) 1984. CODEN: ARPMAS. ISSN: 0365-6233. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Unsym. substituted piperazines I [R1 = Me, R = Me2N, AcNH, 10H-phenothiazin-10-yl, 2-(trifluoromethyl)-10H-phenothiazin-10-yl(Q); R1 = HOCH2CH2, R = Q] and related compds. were mono- and di-N-alkylated by treatment with MeI or PhCH2Br. Where the N substituents are sufficiently different in size monoalkylation is regiospecific under mild conditions. Thus, I (R = Q, R1 = Me) heated 65 h at 40° with MeI gave 52% 1,1-dimethylpiperazinium II. .

6-Chloro-4-isopropylfuro[3,2-b]indole-2-[N-[3-(4-methylpiperazino)prop yl]carboxamide]

6-Chloro-4-isopropylfuro[3,2-b]indole-2-[N-[3-(4-methylpiperazino)prop yl]carboxamide]. Kyogoku, Kazuaki; Kiyoshima, Yoshimoto; Aihara, Hirokazu; Sawada, Jiro (Taisho Pharmaceutical Co., Ltd., Japan). Japan. Kokai JP 53034798 31 Mar 1978 Showa, 3 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D491-04. APPLICATION: JP 76-107209 9 Sep 1976. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 27 Isopropylation of the furoindolecarboxylate I (10 g) by stirring with 1.8 g 50% NaH and 4.7 g Me2CHBr in DMF 3 h at 80° gave 68.4% II. Hydrolysis of II by refluxing with 10% aq. NaOH gave 81% III, which with SOCl2 gave 85.7% acid chloride. The acid chloride (1 g) was amidated by stirring with 1. 4572-03-6 is just another one chemical used in this study.1 g 4-methyl-1-(3-aminopropyl)piperazine in C6H6 2 h to give 57% IV, the tranquilizing activity of which was about 20% greater than that of chlordiazepoxide. 4572-03-6 is just another one chemical used in this study. ..