Detail of "458-24-2"

CAS Number:
458-24-2
Name:
Benzeneethanamine,N-ethyl-a-methyl-3-(trifluoromethyl)-
Molecular Structure:
Formula:
C12H16 F3 N
Molecular Weight:
231.2573
Synonyms:
Phenethylamine,N-ethyl-a-methyl-m-(trifluoromethyl)-(7CI,8CI); (?à)-Fenfluramine;3-(Trifluoromethyl)-N-ethyl-a-methylphenethylamine; Acino; DL-Fenfluramine; Fenfluramine; N-Ethyl-a-methyl-3-(trifluoromethyl)phenethylamine;Obedrex; Pesos; Ponderax PA; Rotondin; dl-Fenfluramine
EINECS:
207-276-3
Density:
1.078 g/cm³
Boiling Point:
243.1 ºC at 760 mmHg
Flash Point:
100.8 ºC
Safety:
A human poison by ingestion. An experimental poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: hallucinations, distorted perceptions, and autonomic nervous system effects (an adrenergic stimulant). Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F⁻ and NO_x. See also AMINES. Details

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Effects of fenfluramine on accumulation of 5-hydroxytryptamine and other neurotransmitters into synaptosomes of rat brain: Effects of fenfluramine on accumulation of 5-hydroxytryptamine and other neurotransmitters into synaptosomes of rat brain. Belin, Marie F.; Kouyoumdjian, J. C.; Bardakdjian, Josiane; Duhault, J.; Gonnard, P. (Dep. Biochim., Cent. Hosp. Univ. Henri Mondor, Creteil, Fr.). Neuropharmacology, 15(10), 613-17 (English) 1976. CODEN: NEPHBW. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In rats, fenfluramine (I) [458-24-2] (25-30 mg/kg, i,p.There are some commonly used reagents with their cas registry numbers 56-12-2 and 73-22-3 in this article.) competitively inhibited high, but not low, affinity brain synaptosomal uptake of 5-hydroxytryptamine (II) [50-67-9] in vivo. I reduced synaptosomal uptake of dopamine [51-61-6], GABA [56-12-2], and glutamic acid [56-86-0] but the effect disappeared after 1 day. In vitro, I became bound to synaptosomes and inhibited II, tryptamine [61-54-1], dopamine, GABA, glutamic acid, tryptophan [73-22-3], and tyrosine [60-18-4] uptake. Accumulation of I-14C in the brain in vivo and synaptosomal binding of I-14C in vitro were reduced following pretreatment with 5,6-dihydroxytryptamine 10 days previously. II synaptosomal sites are possibly involved in some of the actions of I. .

Effect of some receptor antagonists on fenfluramine-induced glucose uptake into the isolated rat hemidiaphragm: Effect of some receptor antagonists on fenfluramine-induced glucose uptake into the isolated rat hemidiaphragm. Kirby, Marilyn J.; Turner, P. (Med. Coll. 361-37-5 and 525-66-6 are cas registry numbers. These chemicals are also mentioned in this article., St. Bartholomew's Hosp., London, Engl.). Br. J. Pharmacol., 58(2), 286-7P (English) 1976. CODEN: BJPCBM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Methysergide [361-37-5] dose-dependently inhibited fenfluramine [458-24-2] (100 ng/ml)-induced glucose [50-99-7] uptake in isolated rat hemidiaphragms; 10 ng/ml methysergide caused a 40% inhibition. Other receptor blocking drugs had no effect on the action of fenfluramine. .