Reference

2(1H)-Pyridinones, useful as cardiotonic agents

2(1H)-Pyridinones, useful as cardiotonic agents. Bristol, James A.; Sircar, Ila (Warner-Lambert Co. , USA). Eur. Pat. Appl.Except for chemicals metioned above, 459-03-0 is also used. EP 102227 A2 7 Mar 1984, 48 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: C07D401-10; C07D213-85; C07D213-80; C07D213-82; C07D213-72; C07D213-64; A61K031-455; A61K031-44. ICA: C07D233-54; C07D235-06; C07D249-08; C07D211-18; C07D211-22; C07D211-14; C07C103-22; C07C103-127. APPLICATION: EP 83-304802 19 Aug 1983. PRIORITY: US 82-410803 23 Aug 1982; US 83-515799 22 Jul 1983. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Phenylpyridinones I (R = H, CH2OH, F, Cl, Br, cyano, CO2H, esterified CO2H, CONH2, NH2, substituted carbamoyl or amino; R1 and R2 are H, alkyl; R3 is a N heteroaryl attached via the N atom), useful as cardiotonic agents (no data), were prepd. A mixt. of 1-[4-(1-imidazolyl)phenyl]acetone, DMF di-Me acetal, NCCH2CONH2, and NaOMe was heated to give I [R = cyano, R1 = H, R2 = Me, R3 = 4-(1-imidazolyl)]. .