Detail of "4594-78-9"

Reference

Low-valence titanium-induced reductive cyclization of d-keto nitriles to cyclopentanones

Low-valence titanium-induced reductive cyclization of d-keto nitriles to cyclopentanones. Chen, Jianxie; Chen, Weixing; Zhang, Junhu; Gao, Jiyu (Dep. Chem., Nanjing Univ. 100869-93-0 and 4594-78-9 are cas registry numbers. These chemicals are also mentioned in this article., Nanjing 210008, Peop. Rep. China). Youji Huaxue, 12(1), 26-9 (Chinese) 1992. CODEN: YCHHDX. ISSN: 0253-2786. DOCUMENT TYPE: Journal CA Section: 24 (Alicyclic Compounds) Reductive cyclization of d-keto nitriles R1COCR2R3CH2CH2CN [R1 = Me, R2 = H, R3 = H, C1-C3 alkyl, PhCH2; R1 = Ph, R2 = H, Me, R3 = Me, Et, R1R2 = (CH2)3, (CH2)4, CHMe(CH2)3, R3 = H] in the presence of TiCl4 and Zn in THF-10% aq. Na2CO3 afforded cyclopentanones I. Similar treatment of MeCOCMe(CH2CH2CN)2 gave bicyclooctanedione II, whereas PhCOCH(CH2CH2CN)2 gave I (R1 = Ph, R2 = H, R3 = CH2CH2CONH2). .

Synthesis of diastereomerically pure racemic 1,2,4-trioxane dimer related to antiproliferative dimers of naturally occurring artemisinin

Synthesis of diastereomerically pure racemic 1,2,4-trioxane dimer related to antiproliferative dimers of naturally occurring artemisinin. Krasavin, M. Yu.; Dorogov, M. V. (Issled. Inst. Khim. Raznoobraziya, Khimki, Russia). Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya, 47(10), 109-113 (Russian) 2004 Ivanovskii Gosudarstvennyi Khimiko-Tekhnologicheskii Universitet. CODEN: IVUKAR. ISSN: 0579-2991. DOCUMENT TYPE: Journal CA Section: 30 (Terpenes and Terpenoids) Section cross-reference(s): 28 A multistep synthesis of a racemic dimer contg. two 1,2,4-trioxane units was performed.Some commonly used reagents like 4594-78-9 is used in this experiment. The trioxane nucleus was formed via Lewis acid catalyzed rearrangement of 1,2-dioxetane precursor upon treatment with trimethylsilyl triflate. Repeated fractionation by column chromatog. followed by HPLC purifn. afforded diastereomerically pure product, structurally similar to previously reported antiproliferative dimers of naturally occurring sesquiterpene artemisinin. .