CAS No.461-78-9,chlorоphentermine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	461-78-9
Name:	chlorоphentermine
Article Data:	8

Formula:	C10H14 Cl N
Molecular Weight:	183.681
Synonyms:	Phenethylamine,p-chloro-a,a-dimethyl- (6CI,8CI);1-(4-Chlorophenyl)-2-methylpropan-2-amine;1-(p-Chlorophenyl)-2-methyl-2-aminopropane;4-Chloro-a,a-dimethylphenethylamine;Chlorphentermine;Clorfentermina;Desopimon;Effox;Lucofen SA;Teramine;p-Chloro-a,a-dimethylphenethylamine;a,a-Dimethyl-4-chlorobenzeneethanamine;
EINECS:	207-314-9
Density:	1.074g/cm³
Boiling Point:	255.8°Cat760mmHg
Flash Point:	127°C
Safety:	Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: blood pressure elevation and sympathetic nervous system stimulation. An experimental teratogen. Mutation data reported. An anorectic drug which diminishes the appetite. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.
PSA:	26.02000
LogP:	3.32010

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Chemistry

IUPAC Name: 1-(4-Chlorophenyl)-2-methylpropan-2-amine
Synonyms of Chlorphentermine (CAS NO.461-78-9) : 1-(4-Chlorophenyl)-2-methylpropan-2-amine ; 4-Chloro-a,a-dimethylbenzeneethanamine ; a,a-Dimethyl-p-chlorophenethylamine ; Avicol ; Benzeneethanamine, 4-chloro-.alpha.,.alpha.-dimethyl-
CAS NO: 461-78-9
Molecular Formula:C₁₀H₁₄ClN
Molecular Weight :183.6779
Molecular Structure :
EINECS: 207-314-9
Index of Refraction: 1.537
Surface Tension: 37.6 dyne/cm
Density: 1.074 g/cm³
Flash Point: 127 °C
Enthalpy of Vaporization: 49.33 kJ/mol
Boiling Point: 255.8 °C at 760 mmHg
Vapour Pressure: 0.016 mmHg at 25°C

History

Chlorphentermine (CAS NO.461-78-9) is developed in 1962, it is the 4-chloro derivative of the better known appetite suppressant phentermine,which is still in current use.Chlorphentermine itself is a relatively weak stimulant with little abuse potential, but is classed as a Schedule 3 drug in the USA due mainly to its similarity to other appetite suppressants such as diethylpropion which have been more widely abused. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.

Uses

Chlorphentermine (CAS NO.461-78-9) (trade names Apsedon, Desopimon, Lucofen) is an appetite suppressant.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	5357ug/kg (5.357mg/kg)	AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Therapie. Vol. 34, Pg. 205, 1979.
mouse	LD50	intraperitoneal	150mg/kg (150mg/kg)		Acta Pharmaceutica Suecica. Vol. 15, Pg. 87, 1978.
mouse	LD50	intravenous	56mg/kg (56mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00697,
mouse	LD50	oral	270mg/kg (270mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: EXCITEMENT	Acta Poloniae Pharmaceutica Vol. 26, Pg. 598, 1969.
mouse	LD50	subcutaneous	260mg/kg (260mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Acta Poloniae Pharmaceutica Vol. 26, Pg. 598, 1969.
rat	LD50	oral	250mg/kg (250mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(6), Pg. 218S, 1969.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: blood pressure elevation and sympathetic nervous system stimulation. An experimental teratogen. Mutation data reported. An anorectic drug which diminishes the appetite. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.