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Detail of "465-65-6"

  • CAS Number:
  • 465-65-6
  • Name:

  • Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, (5a)-

  • Superlist Name:
  • Naloxone
  • Molecular Structure:
  • Formula:
  • C19H21NO4
  • Molecular Weight:
  • 327.37
  • Synonyms:
  • 1-N-Allyl-14-hydroxynordihydromorphinone;1-N-Allyl-7,8-dihydro-14-hydroxynormorphinone;12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furanone;17-Allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one;Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy-;N-Allyl-4,5alpha-epoxy-3,14-dihydroxy-6-morphinanon;N-Allyl-noroxymorphone;NSC 70413;
  • EINECS:
  • 207-365-7
  • Density:
  • 1.43 g/cm3
  • Boiling Point:
  • 532.8 °C at 760 mmHg
  • Flash Point:
  • 276.1 °C
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CAS No.465-65-6 Naloxone

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CAS No.465-65-6 Naloxone

Gladys Actions of enkephalin and morphine on spinal cord and brain stem neurons Actions of enkephalin and morphine on spinal cord and brain stem neurons. Davies, J.; Dray, A. (Dep. Pharmacol., Sch. Pharm., London, Engl.). Br. J. Pharmacol., 58(3), 458P-459P (English) 1976. CODE

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CAS No.465-65-6 Naloxone

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CAS No.465-65-6 Naloxone

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CAS No.465-65-6 Naloxone

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CAS No.465-65-6 Naloxone

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CAS No.465-65-6 Naloxone

Assay:99%  Appearance:white powder  Package:10kg/drum

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CAS No.465-65-6 Naloxone

Almost white or pale yellow, slightly hygroscopic powder

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CAS No.465-65-6 Naloxone

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Reference

Actions of enkephalin and morphine on spinal cord and brain stem neurons
Actions of enkephalin and morphine on spinal cord and brain stem neurons. Davies, J.; Dray, A. (Dep. Pharmacol., Sch. Pharm., London, Engl.). Br. J. Pharmacol., 58(3), 458P-459P (English) 1976. CODEN: BJPCBM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The predominant effects of morphine [57-27-2], methionine enkephalin [58569-55-4], and leucine enkephalin [58822-25-6] on cat spinal cord and rat brain stem neurons were excitatory. E.g. 58822-25-6 and 57-27-2 which are cas registry numbers of substances are two of reagents here., all 3 compds. excited Renshaw cells but not other noncholinoceptive interneurons in spinal cord, the excitation being reversibly reduced by naloxone [465-65-6]. Methionine enkephalin was a more potent effective excitant than leucine enkephalin. Thus enkephalins act on central opiate receptors and may be the endogenous ligand for the stereospecific opiate receptor. .
Opiates, cyclic nucleotides, and xanthines
Opiates, cyclic nucleotides, and xanthines. Collier, H. O. J.; Francis, D. L.; Roy, A. C. (Miles Lab. Ltd., Stoke Poges/Slough, Engl.). Adv. Biochem. Psychopharmacol. 11042-70-9 and 9036-21-9 are cas registry numbers of chemicals which are used as reagents here., 15(First Second Messengers - New Vistas), 337-45 (English) 1976. CODEN: ABPYBL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Opiates inhibited prostaglandin E [11042-70-9]-stimulated cyclic AMP (I) [60-92-4] formation in rat brain homogenate. Naloxone [465-65-6] antagonized heroin without itself inhibiting the I formation. In morphine [57-27-2]-dependent rats, intracerebroventricular injection of I intensified and of dibutyryl cyclic GMP [32266-35-6] diminished precipitated abstinence effects. In naive rats, the xanthines, theophylline [58-55-9] and 3-isobutyl-1-methylxanthine [28822-58-4], produced a quasimorphine-abstinence syndrome that was readily suppressed by heroin and intensified by naloxone. In rat brain homogenate, these xanthines inhibited cyclic AMP phosphodiesterase [9036-21-9]. .
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