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466-06-8

Basic Information
CAS No.: 466-06-8
Name: PROSCILLARIDIN A
Molecular Structure:
Molecular Structure of 466-06-8 (PROSCILLARIDIN A)
Formula: C30H42 O8
Molecular Weight: 530.659
Synonyms: ProscillaridinA (6CI,7CI,8CI); 14-Hydroxy-3b-(rhamnosyloxy)bufa-4,20,22-trienolide; 3b-Rhamnosido-14b-hydroxy-D4,20,22-bufatrienolide; 3b-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide;A 32686; Caradrin; Cardion; Cardiovite; Carmazon; Coratol;Desglucotransvaaline; Desglucotrnasvaaline; Herzo Proscillan; NSC 7521;PSC-801; Procardin; Procilan; Proscillan; Proscillaridin; Prostosin; Proszine;Protasin; Purosin-TC; Sandoscill; Scillacrist; Scillarenin 3b-rhamnoside; Simeon; Solestril;Stellarid; Talucard; Talusin; Tradenal; Transvaalin, degluco-; Urgilan;Wirnesin
Density: 1.33g/cm3
Melting Point: 233°C
Boiling Point: 716.7°Cat760mmHg
Flash Point: 232.6°C
Hazard Symbols:
Risk Codes: 25
Safety: Poison by ingestion, intravenous, and intraduodenal routes. When heated to decomposition it emits acrid smoke and irritating fumes.
PSA: 129.59000
LogP: 3.01380
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Chemistry

IUPAC Name: 5-[(3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy1,2,3,6,7,8,9,11,12,15,16,17-
dodecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one
Synonyms: Scillarenin 3beta-rhamnoside ; Proscillaridin ; Proscillaridin A; ((6-Deoxy-alpha-l-mannopyranosyl)oxy)-14-hydroxybufa-4,20,22-trienolide ; 14-Hydroxy-3-beta-(rhamnosyloxy)bufa-4,20,22-trienolide ; 22-Trienolide,3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-14-hydroxy-bufa-20  ;22-Trienolide,3-beta-((6-deoxy-alpha-l-mannosyl)oxy)-14-hydroxy-bufa-20 ; 3-Beta-((6-deoxy-alpha-l-mannopyranosyl)oxy)-14-hydroxybufa-4,20,22-trienoli
CAS NO: 466-06-8
Molecular Formula: C30H42O8
Molecular Weight: 530.65
Molecular Structure:
EINECS: 207-370-4
Product Categories:
Mol File: 466-06-8.mol
Index of Refraction: 1.619
Surface Tension: 62.3 dyne/cm
Density: 1.33 g/cm3
Flash Point: 232.6 °C
Enthalpy of Vaporization: 119.66 kJ/mol
Boiling Point: 716.7 °C at 760 mmHg
Vapour Pressure: 1E-23 mmHg at 25°C
Melting point: 233°C
Storage temp: Keep Proscillaridin (CAS NO.466-06-8) at 2-8°C

Uses

Proscillaridin (CAS NO.466-06-8) is clinically used as a tonic,mainly used for heart valve disease, ischemic heart disease and hypertensive heart disease

Toxicity Data With Reference

1.    

orl-rat LD50:56 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 20 (1971),599.
2.    

ivn-rat LD50:9 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 20 (1971),599.
3.    

orl-mus LD50:30,500 µg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),723.
4.    

ivn-mus LD50:23,200 µg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),723.
5.    

ivn-cat LD50:111 µg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 20 (1970),1.
6.    

idu-cat LDLo:268 µg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 14 (1964),716.
7.    

orl-gpg LD50:6810 µg/kg

    USXXAM    United States Patent Document. (Commissioner of Patents and Trademarks, Washington, DC 20231) #4230702 .
8.    

ivn-gpg LD50:280 µg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 20 (1970),1.

Safety Profile

Poison by ingestion, intravenous, and intraduodenal routes. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes ToxicT
Risk Statements 25
R25 : Proscillaridin (CAS NO.466-06-8) is toxic if swallowed.
Safety Statements 28-45 
S28:After contact with skin, wash immediately with plenty of soap-suds. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS UK6650000