Detail of "4678-45-9"

CAS Number:
4678-45-9
Name:
Grayanotoxane-3,5,6,10,14,16-hexol,(3b,6b,14R)-
Molecular Structure:
Formula:
C20H34 O6
Molecular Weight:
370.54
Synonyms:
GrayanotoxinIII (6CI,7CI); (-)-Grayanotoxin III; Andromedol; Deacetylandromedotoxin;Deacylasebotoxin I; FDA 1962; NSC 323778
Hazard Symbols:
A poison.
Safety:
A poison by intravenous route. Moderately toxic by intraperitoneal route. When heated to decomposition it emits acrid smoke and irritating vapors. Details
Source:
Natural product.

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Centrifugal partition chromatography of grayanane compounds: Centrifugal partition chromatography of grayanane compounds. Terai, Tadamasa (Dep. Appl. Chem., Osaka Inst. Technol., Osaka 535, Japan). Nippon Nogei Kagaku Kaishi, 59(5), 515-18 (Japanese) 1985. CODEN: NNKKAA. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Grayanotoxin I (G-I)(I) [4720-09-6], grayanotoxin II (G-II) [4678-44-8], and grayanotoxin III (G-III) [4678-45-9] were sepd. by a centrifugal partition chromatog. method using a solvent system of :40 CHCl3-MeOH-H2O (mobile phase, upper layer; stationary phase, lower layer) at a rotational speed of 700 rpm and a flow rate of 1 mL/min. The rotor of the centrifuge contained 12 column cartridges connected with each other in series. G-I, G-II, and G-III (5 mg each) were injected into the system. The constituents in the eluate were checked by TLC and quant. detd. at 460 nm after being treated with vanillin in a soln. of HClO4.

Determination of grayanotoxin I, II and III by thin-layer chromatography: Determination of grayanotoxin I, II and III by thin-layer chromatography. Terai, Tadamasa (Dep. Appl. Chem., Osaka Inst. Technol., Asahi 535, Japan). Nippon Nogei Kagaku Kaishi, 58(11), 1117-22 (Japanese) 1984. CODEN: NNKKAA. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) A thin-layer chromatog. method was developed for the identification and quant. detn. of grayanotoxin I [4720-09-6], grayanotoxin II [4678-44-8], and grayanotoxin III [4678-45-9]. The optimum conditions were EtOAc-MeOH () as developing solvent, Merck Kieselgel 60 thin layer with 40% H2O, and 20% phosphotungstic acid in EtOH spray with 90° charring temp. for 20 min for spot detection. The spots were detected on a Chromatoscanner CS-920 at 492 nm. The calibration curves were linear for 0.5-2.5 mg/spot for std. samples with correlation coeffs. of 0.9987 for I, 0.9994 for II, and 0.9962 for III.