Detail of "469-83-0"

Reference

Separate effects of the coffee diterpenes cafestol and kahweol on serum lipids and liver aminotransferases

Separate effects of the coffee diterpenes cafestol and kahweol on serum lipids and liver aminotransferases. Urgert, Rob; Essed, Natasja; van der Weg, Guido; Kosmeijer-Schuil, Truus; Katan, Martijn B. (Dept. of Human Nutrition, Wageningen Agricultural Univ., Wageningen, Neth.). American Journal of Clinical Nutrition, 65(2), 519-524 (English) 1997 American Society for Clinical Nutrition. CODEN: AJCNAC. ISSN: 0002-9165. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) The coffee diterpene cafestol occurs in both robusta and arabica beans. It is present in unfiltered coffee brews and raises serum concns. of cholesterol, triacylglycerols, and alanine aminotransferase in humans. The effects are linear with the cafestol dose. Unfiltered coffee also contains the related compd. kahweol, which occurs only in the major coffee strain arabica. The activity of kahweol is unknown.There are some reagents with their cas registry numbers 469-83-0 and 9046-27-9 are used in this study. In a randomized, double-blind crossover study, we gave 10 healthy male volunteers either pure cafestol (61-64 mg/d) or a mixt. of cafestol (60 mg/d) and kahweol (48-54 mg/d) for 28 d. Relative to baseline values, cafestol raised man (± SEM) total serum cholesterol concns. by 0.79 ± 0.14 mmol/L (31 ± 5 mg/dL), low-d.-lipoprotein (LDL) cholesterol by 0.57 ± 0.13 mmol/L (22 ± 5 mg/dL), fasting triacylglycerols by 0.65 ± 0.12 mmol/L (58 ± 11 mg/dL), and alanine aminotransferase by 18 ± 2 U/L (all P<0.01). Relative to cafestol alone, the mixt. of cafestol plus kahweol increased total cholesterol by another 0.23 ± 0.16 mmol/L (9 ± 6 mg/dL) (P=0.08), LDL cholesterol by 0.23 ± 0.16 mmol/L (9 ± 6 mg/dL) (P=mg/dL) (P=0.09), triacylglycerols by 0.09 ± 0.10 mmol/L (8 ± 9 mg/dL) (P=20), and alanine aminotransferase by 35 ± 11 U/L (P = 0.004). Thus, the effect of cafestol on serum lipid concns. was much larger than the addnl. effect of kahweol, and the hyperlipidemic potential of unfiltered coffee mainly depends on its cafestol content. Both cafestol and kahweol raised alanine aminotransferase concns., and their hyperlipidemic effect thus seems not to be coupled with their effect on liver cells. .

The cholesterol-raising factor from coffee beans

The cholesterol-raising factor from coffee beans.Some chemicals with cas registry numbers like 469-83-0 and 6894-43-5 are also used. Urgert, R.; Katan, M. B. (Dep. Human Nutrition, Wageningen Agricultural Univ., Wageningen 6703, Neth.). Journal of the Royal Society of Medicine, 89(11), 618-623 (English) 1996 Royal Society of Medicine Press. CODEN: JRSMD9. ISSN: 0141-0768. DOCUMENT TYPE: Journal; General Review CA Section: 17 (Food and Feed Chemistry) A review with 60 refs. Coffee beans and some types of coffee brew (not the regular types of coffee prepd. with a paper filter or with sol. coffee granules) contain the diterpenes cafestol and kahweol. Cafestol and kahweol raise the serum concn. of cholesterol and triglycerides in humans, and they also appear to slightly affect the integrity of liver cells. Both effects are transient after withdrawal of the diterpenes, and it is as yet unsure whether these effects are assocd. Patients at increased risk of heart disease who drink large amts. of coffee should be advised to select brews low in diterpenes. .