Detail of "4696-76-8"

Reference

Transposable multiple antibiotic resistance in Streptococcus pneumoniae

Transposable multiple antibiotic resistance in Streptococcus pneumoniae. Courvalin, Patrice; Carlier, Cecile (Unite Agents Antibact., Inst. Pasteur, Paris F-75724, Fr.). MGG, Mol. Gen. Genet., 205(2), 291-7 (English) 1986. CODEN: MGGEAE. ISSN: 0026-8925. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Genetics) A mobile genetic element, designated Tn1545, was detected in the chromosome of S. pneumoniae BM4200, a clin. isolate multiply resistant to antibiotics. The 25.3-kb element conferred resistance to kanamycin [4696-76-8] and structurally related aminoglycosides by synthesis of a 3'-aminoglycoside phosphotransferase type III [58500-41-7] (aphA-3), to macrolide-lincosamide-streptogramin B [3131-03-1]-type antibiotics (ermAM), and to tetracycline [60-54-8] (tetM). Tn1545 was self-transferable to a recombination-deficient S. faecalis strain in which it was able to transpose to various sites, induce insertional mutations, and was apparently cleanly excised. The element also conjugated and transposed to the chromosome of S. faecalis, S. lactis, S. diacetylactis, S. cremoris, S. sanguis, Staphylococcus aureus, and Listeria monocytogenes. The properties of the conjugative transposon Tn1545 could account for the sudden emergence, rapid dissemination, and stabilization of multiple resistance to antibiotics in S. pneumoniae in the absence of plasmids.

Plasma levels and urinary concentrations of kanamycin, bekanamycin, and amikacin (BBK 8) in young diabetics and a control group

Plasma levels and urinary concentrations of kanamycin, bekanamycin, and amikacin (BBK 8) in young diabetics and a control group. Garcia P., Gabriel; De Vidal, Esther Luisa; Trujillo S., Hugo (Dep. Pediatr., Univ. Antioquia, Medellin, Colombia). Invest. Med. Int., 4(2), 167-71 (Spanish) 1977. CODEN: IMEIDH. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Peak plasma antibiotic levels were obsd. at 1 h after i.m. administration of kanamycin [8063-07-8] (7.5 mg/kg), bekanamycin [4696-76-8] (7.5 mg/kg), and amikacin [37517-28-5] (4 mg/kg) in both control and diabetic 6-15-year-old children. With the exception of 1 of the 9 diabetics examd., plasma antibiotic concns. were consistently lower in the diabetics than in the controls up to 6 h after drug administration. Urinary elimination of the antibiotics was generally lower in the diabetics than in the controls.