CAS No.4696-76-8,Bekanamycin Suppliers

Products Categories

Pharmaceutical (62)
Organic Chemicals (14)
Others (2)
Reagent (1)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	4696-76-8
Name:	Bekanamycin
Article Data:	2

Formula:	C18H37 N5 O10
Molecular Weight:	483.519
Synonyms:	KanamycinB (7CI,8CI); 2'-Amino-2'-deoxykanamycin; Aminodeoxykanamycin; Bekanamycin; KDM;Kanendomycin; NK 1006; Nebramycin V; Nebramycin factor 5
EINECS:	225-170-5
Density:	1.59g/cm³
Melting Point:	178-182° (dec)
Boiling Point:	807.7°Cat760mmHg
Flash Point:	442.3°C
Safety:	Poison by intravenous route. Moderately toxic by intraperitoneal and subcutaneous routes. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	288.40000
LogP:	-3.82350

Synthetic route

: 24424-99-5
di-tert-butyl dicarbonate

: 4696-76-8
kananmycin B

: 1,3,2',6',3''-penta-N-tert-butoxycarbonyl kanamycin B

Conditions

Conditions	Yield
With sodium carbonate In water; isopropyl alcohol at 30℃; for 6h; Temperature;	94%

: 98-59-9
p-toluenesulfonyl chloride

: 4696-76-8
kananmycin B

: 60929-91-1, 119818-17-6
1,3,2',6',3''-penta-N-p-toluenesulfonylkanamycin B

Conditions

Conditions	Yield
With sodium carbonate In ethanol; dichloromethane; water at 25℃; for 16h; Reagent/catalyst; Solvent; Temperature;	92.3%

: 24424-99-5
di-tert-butyl dicarbonate

: 4696-76-8
kananmycin B

: 64271-30-3
1,3,2',6',3''-penta-N-BOC-kanamycin B

Conditions

Conditions	Yield
In water; dimethyl sulfoxide at 60℃; for 6h;	90%

: 139705-38-7
acetone O-<(vinyloxy)carbonyl>oxime

: 4696-76-8
kananmycin B

: C33H47N5O20

Conditions

Conditions	Yield
In phosphate buffer at 0℃; for 5h; pH=8.0;	84%

: 4696-76-8
kananmycin B

: 207857-15-6
1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

: guanidinoboc10-kanamycin B

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water at 20℃;	80%

: 4696-76-8
kananmycin B

: 1268528-26-2
pentaazidokanamycin B

Conditions

Conditions	Yield
With triflic azide; triethylamine; zinc(II) chloride In methanol; water at 20℃; Inert atmosphere;	76%
Stage #1: kananmycin B With copper(II) sulfate In water for 0.25h; Stage #2: With triethylamine In water for 0.333333h; Cooling with ice; Further stages;	1.66 g

: 24424-99-5
di-tert-butyl dicarbonate

: 4696-76-8
kananmycin B

: 132260-09-4
3,2',6'-tris-N-(tert-butoxycarbonyl)kanamycin B

Conditions

Conditions	Yield
Stage #1: kananmycin B With zinc(II) acetate dihydrate In dimethyl sulfoxide at 21℃; Stage #2: di-tert-butyl dicarbonate In dimethyl sulfoxide at 21℃; for 5h;	66%
With zinc diacetate 1.) DMSO, RT, overnight, 2.) 5 h; Yield given. Multistep reaction;

: 4696-76-8
kananmycin B

: 207857-15-6
1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

: 320616-55-5
C73H127N15O30

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water at 20℃; for 72h;	65%

: 108-24-7
acetic anhydride

: 4696-76-8
kananmycin B

: 144727-28-6
penta-N-hexa-O-acetylkanamycin B

Conditions

Conditions	Yield
With pyridine

: 104-15-4
toluene-4-sulfonic acid

: 4696-76-8
kananmycin B

: 60929-91-1, 119818-17-6
1,3,2',6',3''-penta-N-p-toluenesulfonylkanamycin B

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 2h; Ambient temperature;

Total:69 Page 1 of 2 1 2 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 4696-76-8

Chemistry

Molecular Formula: C₁₈H₃₇N₅O₁₀
Molar mass: 483.5139 g/mol
EINECS: 225-170-5
Density: 1.59 g/cm³
Flash Point: 442.3 °C
Index of Refraction: 1.668
Boiling Point: 807.7 °C at 760 mmHg
Vapour Pressure: 3.43E-30 mmHg at 25°C
Product categories of Bekanamycin (4696-76-8): Pharmaceutical Intermediates
Structure of Bekanamycin (4696-76-8):

XLogP3-AA: -7.2
H-Bond Donor: 11
H-Bond Acceptor: 15
IUPAC Name: (2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4-diol
Canonical SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)N)N
Isomeric SMILES: C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)N)N
InChI: InChI=1S/C18H37N5O10/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18/h4-18,24-29H,1-3,19-23H2/t4-,5+,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1
InChIKey: SKKLOUVUUNMCJE-FQSMHNGLSA-N

Uses

Bekanamycin (4696-76-8) has been used for the antibiotic medicine, and is also used as the intermediates of the production of Sulfuric acid in the Bekaa star and Arbekacin .

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	800mg/kg (800mg/kg)	"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 159, 1980.
mouse	LD50	intravenous	132mg/kg (132mg/kg)	Journal of Antibiotics. Vol. 27, Pg. 677, 1974.
mouse	LD50	oral	> 10gm/kg (10000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 11, Pg. 1901, 1969.
mouse	LD50	subcutaneous	750mg/kg (750mg/kg)	"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 159, 1980.
rat	LD50	intramuscular	1420mg/kg (1420mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 11, Pg. 1901, 1969.
rat	LD50	intraperitoneal	1400mg/kg (1400mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 11, Pg. 1901, 1969.
rat	LD50	intravenous	141mg/kg (141mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 11, Pg. 1901, 1969.
rat	LD50	oral	> 10gm/kg (10000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 11, Pg. 1901, 1969.
rat	LD50	subcutaneous	1900mg/kg (1900mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 11, Pg. 1901, 1969.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal and subcutaneous routes. When heated to decomposition it emits toxic fumes of NO_x.

Specification

Bekanamycin (4696-76-8) also can be called Aminodeoxykanamycin and Kanamycin B .