Reference

The structure and biological effect of leonurine

The structure and biological effect of leonurine. A uterotonic principle from the Chinese drug, I-mu Ts'ao. Yeung, H. W.; Kong, Y. C.; Lay, W. P.; Cheng, K. F. (Dep. Biochem., Chin. Univ. Hong Kong, Shatin, Hong Kong). Planta Med., 31(1), 51-6 (English) 1977. CODEN: PLMEAA. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 31, 11 Leonurine (I) [24697-74-3], a uterotonic alkaloid, was obtained by column chromatog. of the acidic MeOH ext. of the plants of Leonurus artemisia. The plants are used for their cure in obstetrical and gynecol. disorders. I was assigned the structure from its spectral data and comparison with authenic material. A uterotonic effect of I was obsd. at .gtoreq.0.4 .mu.g/mL on actively contracting rat uterine prepns. Stachydrine [471-87-4], a 2nd alkaloid, was also isolated.

Separation and determination of alkaloids of Leonurus sibiricus

Separation and determination of alkaloids of Leonurus sibiricus. Luo, Shurong; Mai, Lu; Zhu, Zhaoyi (Inst. Pharmacol., Chin. Acad. Med. Sci., Beijing, Peop. Rep. China). Zhongyao Tongbao, 10(1), 32-5 (Chinese) 1985. CODEN: CYTPDT. ISSN: 0254-0029. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Powder of the whole plant of L. sirbiricus was extd. with EtOAc and the ext. was concd. and dissolved in distd. H2O. After diln. with MeOH, an aliquot was chromatographed on silica gel G plates by using BuOH-HCl-EtOAc (4:1.5:0.5) as eluent. Spots were visualized by treatment with the modified Dragendoff reagent and subjected to anal. by dual-wavelength densitometry for the detn. of leonurine [24697-74-3] and stachydrine [471-87-4]. The calibration plot was linear in the range of 0-12 mg. Recoveries of added leonurine were 97.1% and those of added stachydrine were 98.81%. Reproducibility with a relative std. deviation of 2.5-4.3% was obsd.