Detail of "4747-21-1"

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Convenient preparation of pure N-methylalkanamines by reduction with zinc/hydrochloric acid of 1,3,5-trialkyl(hexahydro)-1,3,5-triazines

Convenient preparation of pure N-methylalkanamines by reduction with zinc/hydrochloric acid of 1,3,5-trialkyl(hexahydro)-1,3,5-triazines. Al Shaik, Mohammed; Oelschlaeger, Herbert (Inst. Pharm. Chem.Chemicals with cas numbers 109-73-9 and 4747-21-1 also play role., Johann Wolfgang Goethe-Univ., Frankfurt/Main 6000, Fed. Rep. Ger.). Arch. Pharm. (Weinheim, Ger.), 317(3), 214-19 (German) 1984. CODEN: ARPMAS. ISSN: 0365-6233. DOCUMENT TYPE: Journal CA Section: 21 (General Organic Chemistry) Title amines RNHMe (R = allyl, Pr, Bu, Me2CHCH2, Me3C, cyclohexyl) of ~95% purity were prepd. by reducing appropriate triazines I with Zn/HCl at -5° using a drop-in procedure. .

Method for removing cyanoethyl group in synthesis of oligodeoxyribonucleoside alkylphosphonates

Method for removing cyanoethyl group in synthesis of oligodeoxyribonucleoside alkylphosphonates. Kaji, Akira (Japan).Several substances are used for example 4747-21-1 which is its cas registry number. Jpn. Kokai Tokkyo Koho JP 62042997 A2 24 Feb 1987 Showa, 7 pp. (Japan) CODEN: JKXXAF. CLASS: ICM: C07H019-10. ICS: C07H019-20; C07H021-04. APPLICATION: JP 85-180494 19 Aug 1985. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) A cyanoethyl group in (oligo)deoxynucleoside alkylphosphonates (I; R = C<5 alkyl; R1 = CH2CH2CN; R2 = protecting group; B = amino protected nucleoside base; n 3 1) was removed by treatment with one or more than one amines selected from Me2CHNH2, Me2CHCH2NH2, MeCHEtNH2, Me3CNH2, MeCH2CH2NHMe, Me2CHNHMe, Et2NH, MeCH2CH2NHEt, Me2CHNHEt, Me2CHNHPr, and (iso-Pr)2NH in the synthesis of I (R1 = H) by the triester method. The use of amines as a base had advantages over NaOH and provided high yield, clean and controlled deprotection of a cyanoethyl group. Thus, a soln. of 0.84 g cyanoethyl 5'-dimethoxytrityl-N-benzoyldeoxycytidine 3'-methylphosphonate in 2 mL anhyd. pyridine and 3 mL Et2NH was allowed to react at room temp. for 1 h to give, after evapn. of the solvent in vacuo, 100% 5'-(dimethoxytrityl)-N-benzoylcytidine 3'-methylphosphonate. .