Detail of "4747-98-2"

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Illicit heroin manufacturing by-products: capillary gas chromatographic determination and structural elucidation of narcotine- and norlaudanosine-related compounds

Illicit heroin manufacturing by-products: capillary gas chromatographic determination and structural elucidation of narcotine- and norlaudanosine-related compounds. Allen, Andrew C.; Cooper, Donald A.; Moore, James M.; Gloger, Manfred; Neumann, Helmut (Spec. Test. Res. Lab., Drug Enforc. Adm., McLean, VA 22102, USA).Several reagents such as 91295-74-8 is used here. Anal. Chem., 56(14), 2940-7 (English) 1984. CODEN: ANCHAM. ISSN: 0003-2700. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Capillary gas chromatog. methodol. was described for the detection of trace quantities of narcotine [128-62-1]- and norlaudanosine-related manufg. impurities in illicit heroin (I) [561-27-3]. N-Acetylnornarcotine [92543-13-0], (Z)- [92543-23-2] and (E)-N-acetylanhydronornarceine [92543-15-2], (1R,9S)- [92543-24-3] and (1R,9R)-1-acetoxy-N-acetylanhydro-1,9-dihydronornarceine [92543-16-3], and (E)-3-[2-[2-(N-methylacetamido)ethyl]-4,5-(methylenedioxy)-6-metho xy)phenyl]acrylic acid [92543-14-1] result from the reaction of narcotine with Ac2O. The treatment of norlaudanosine [4747-98-2] with Ac2O yields N-acetylnorlaudanosine [860-23-1]. After isolation from the bulk heroin matrix, these impurities, along with morphine, codeine, and thebaine byproducts, are detected by using both fused silica and glass capillary columns in the split mode with flame ionization detection. The syntheses and spectral characterization of these impurities are described. .