Detail of "475-75-2"

Reference

Studies on the chemical constituents of rutaceous plants

Studies on the chemical constituents of rutaceous plants. LIX. The chemical constituents of Xanthoxylum nitidum (Roxb.) D.C. (Fagara nitida Roxb.) (1). Examination of the alkaloidal fraction of the bark. Ishii, Hisashi; Ishikawa, Tsutomu; Akaike, Misako; Tohjoh, Toshiaki; Toyoki, Masanao; Ishikawa, Munekazu; Chen, Ih Sheng; Lu, Sheng Teh (Fac. Pharm. Sci., Chiba Univ., Chiba 260, Japan). Yakugaku Zasshi, 104(10), 1030-42 (Japanese) 1984. CODEN: YKKZAJ. ISSN: 0031-6903. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 11 The chem. constituents in the alkaloidal fraction of Formosan X. nitridum (ROXB.) D.C. (F. nitida ROXB.) bark (Japanese name: Teriha-Zansho), Rutaceae, which was collected in the area of Ping-Tung Hsien, were examd. Twelve alkaloids, nitidine (I) [6872-57-7], oxynitidine [548-31-2], 6-methoxy-5,7-dihydrochelerythrine [49702-49-0], oxychelerythrine [28342-33-8], des-N-methylchelerythrine (II) [6900-99-8], chelerythrine [34316-15-9], arnottianamide [60394-88-9], liriodenine [475-75-2], bocconoline [32906-88-0], decarine [54354-62-0], integriamide [72459-16-6], and isoarnottianamide [60394-91-4], and 3 lignans l-asarinin [133-04-0], l-sesamin [13079-95-3], and l-syringaresinol [6216-82-6], a coumarin, aesculetin di-Me ether [120-08-1], together with b-sitosterol [83-46-5] were isolated. Other than the above 17 known compds. a new phenolic benzo[c]phenanthridone alkaloid designated as oxyterihanine (III) [95066-54-9] was also isolated as a minor component. While the past 3 groups reported that nitidine was a sole quaternary benzo[c]phenanthridine alkaloid in the same plants collected in the areas of Hong-Kong and of China mainland (Gauanx and Gauantung), II was isolated as a major component. I was isolated from the plant collected in Mar. as a second component, but I was essentially a sole benzo[c]phenanthridine alkaloid in the case of the plant collected in July and Sept. The seasonal variation of the contents of the quaternary benzo[c]phenanthridine alkaloids is discussed.

Antimicrobial compositions

Antimicrobial compositions. Hufford, Charles D. (University of Mississippi, USA). U.S. US 4093717 6 Jun 1978, 5 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K035-78. NCL: 424195000. APPLICATION: US 75-596282 16 Jul 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 3, 11 Antimicrobial exts. and alkaloids are obtained by extn. of ground heartwood of Liriodendron tulipitera. Dehydroglaucine [22212-26-6] and liriodenine (I) [475-75-2] were isolated. I and I.MeI [55974-07-7] showed in vitro antimicrobial activity comparable to that of streptomycin sulfate and amphotericin B. Dehydroglaucine had a similar spectrum of activity to I and I.MeI but was not as potent. Oxoglaucine methiodide [55974-08-8], prepd. by oxidn. of glaucine [475-81-0] and treatment with MeI, had similar activity to dehydroglaucine but is particularly active against Candida albicans.