Detail of > 475-80-9
- CAS Number:
- 475-80-9
- Name:
Phenanthro[3,4-d]-1,3-dioxole-5-carboxylicacid, 6-nitro-
- Formula:
- C16H9 N O6
- Molecular Structure:
![Molecular Structure of 475-80-9 (Phenanthro[3,4-d]-1,3-dioxole-5-carboxylicacid, 6-nitro-)](http://www.lookchem.com/300w/2010/0621/475-80-9.jpg)
- Synonyms:
- Aristolochic acidII (6CI); 3,4-(Methylenedioxy)-10-nitrophenanthrene-1-carboxylic acid;Aristolochic acid B
- Molecular Weight:
- 311.26
- EINECS:
- 207-499-6
- Density:
- 1.61 g/cm3
- Boiling Point:
- 592.2 °C at 760 mmHg
- Flash Point:
- 311.9 °C
- Safety:
- Mutation data reported. When heated to decomposition it emits toxic vapors of NOx.Details
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Reference
- Mutagenicity of the two components of commercially available carcinogenic aristolochic acid in Salmonella typhimurium
- Mutagenicity of the two components of commercially available carcinogenic aristolochic acid in Salmonella typhimurium. Schmeiser, H. H.; Pool, B. L.; Wiessler, M. (Inst. Toxicol. Chemother., German Cancer Res. Cent., Heidelberg 6900, Fed. Rep. Ger.). Cancer Lett. (Shannon, Irel.), 23(1), 97-101 (English) 1984. CODEN: CALEDQ. ISSN: 0304-3835. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The mutagenicity of aristolochic acid I (AAI)(I) [313-67-7] (isolated) and aristolochic acid II (AAII)(II) [475-80-9] (enriched), the 2 main components of aristolochic acid (AA), was studied. Three different AA samples (AAI 99% pure; AAI 65; + AAII 35%; AAI 32% + AAII 68%) were assayed in S. typhimurium strains TA1537, TA100, and TA100 NR. AAI and AAII were direct mutagens in Salmonella strains TA1537 and TA100 with almost equal mutagenic potency. In TA100 NR, the AA samples showed no or only a very low level of biol. activity, indicating the necessity of nitro-group redn. for the bioactivation of the samples. Apparently, both AAI as well as AAII can be used in further studies to elucidate the metab. of AA.
- Mutagenicity and in vitro metabolism of aristolochic acid
- Mutagenicity and in vitro metabolism of aristolochic acid. Schmeiser, H. H.; Pool, B. L.; Wiessler, M. (Inst. Toxicol. Chemother., Ger. Cancer Res. Cent., Heidelberg D-6900, Fed. Rep. Ger.). Biochem. Pharmacol., 34(3), 455-6 (English) 1985. CODEN: BCPCA6. ISSN: 0006-2952. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Under aerobic conditions, >90% of aristolochic acid I (I) [313-67-7] added to rat liver supernatant (9000g) was metabolized whereas no measurable metab. of aristolochic acid II (II) [475-80-9] had occurred after 180 min; under anaerobic conditions, ~60% of II and only 10% of I was metab. When II was incubated with DNA in S-9 mix 2 arom. carcinogen DNA adducts of undetd. structure were formed.
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