Reference

Effect of ellagic and caffeic acids on covalent binding of benzo[a]pyrene to epidermal DNA of mouse skin in organ culture

Effect of ellagic and caffeic acids on covalent binding of benzo[a]pyrene to epidermal DNA of mouse skin in organ culture. Shugart, Lee; Kao, John (Biol. Div., Oak Ridge Natl. Lab., Oak Ridge, TN 37830, USA). Int. J. Biochem., 16(5), 571-3 (English) 1984. CODEN: IJBOBV. ISSN: 0020-711X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The covalent binding of the anti-diol epoxide of benzo[a]pyrene [r-7, t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydro[a]pyrene (BaPDE) [60268-85-1]] to cellular DNA of mouse skin in organ culture is affected by the presence of ellagic acid (I) [476-66-4] in the culture medium. At 10-4M, BaPDE/DNA formation is 40% less than that obsd. when no I is present. Caffeic acid [331-39-5], a similar plant phenolic compd., demonstrates no inhibitory effect on BaPDE formation. The plant phenolic acids do not drastically interfere with the metab. of benzo[a]pyrene [50-32-8] as shown by the BaP-metabolite profiles of the skin or of the culture medium.

A study of chemicals in the wood and associated industries for the selection of candidates for carcinogen bioassay

A study of chemicals in the wood and associated industries for the selection of candidates for carcinogen bioassay. 1. Naturally occurring wood chemicals. Sigman, C. C.; Helmes, C. T.; Fay, J. R.; Lundquist, P. L.; Perry, L. R. (SRI Int., Menlo Park, CA 94025, USA). J. Environ. Sci. Health, Part A, A19(5), 533-77 (English) 1984. CODEN: JESEDU. ISSN: 0360-1226. DOCUMENT TYPE: Journal; General Review CA Section: 4 (Toxicology) Section cross-reference(s): 43 A review and discussion with 61 refs. Based on consideration of possible carcinogenic activity and evidence indicating potential exposure, the following naturally occurring 11 chems. were nominated for carcinogen bioassay: abietic acid [514-10-3], cardol [57486-25-6], urushiol [53237-59-5], coniferyl aldehyde [458-36-6], ellagic acid [476-66-4], kaempferol (I) [520-18-3], lapachol [84-79-7], 4-methoxydalbergione [28396-75-0], podophyllotoxin [518-28-5], pterostilbene [537-42-8], and a-terpineol [98-55-5].