Detail of "47623-98-3"

CAS Number:
47623-98-3
Name:
4,6(1H,5H)-Pyrimidinedione,5-[3-(1,3-diethylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propen-1-ylidene]-1,3-diethyldihydro-2-thioxo-
Superlist Name:
Bis(1,3-diethylthiobarbituric acid)trimethine oxonol
Molecular Structure:
Formula:
C19H24 N4 O4 S2
Molecular Weight:
602.64
Synonyms:
4,6(1H,5H)-Pyrimidinedione,5-[3-(1,3-diethylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propenylidene]-1,3-diethyldihydro-2-thioxo-(9CI); Bis(1,3-diethylthiobarbituric acid)trimethine oxonol; DiSBAC2(3)
Safety:
Safety Statements 24/25
Details

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Membrane potential based assays for ion channels and electrogenic transporters: All Rights Reserved. Membrane potential based assays for ion channels and electrogenic transporters. Lu, Qiang; Lin, Stephen; Dunlop, John (Neuroscience Discovery Research, Wyeth Research, Princeton, NJ, USA).There are some reagents with their cas registry numbers 393782-57-5 and 47623-98-3 are used in this study. Drug Discovery Series, 5(Handbook of Assay Development in Drug Discovery), 343-356 (English) 2006 CRC Press LLC. CODEN: DDSRBS. DOCUMENT TYPE: Journal; General Review CA Section: 9 (Biochemical Methods) This review on the application of membrane potential dyes in developing ion channel assays, including typical voltage-dependent ion channels, ligand-gated ion channels and electrogenic transporters. It primarily covers two major platforms for fluorescence based membrane potential assays: a one-dye system that uses the fluorometric imaging plate reader (FLIPR) or FLEX station and membrane potential (FMP) and a two-dye system using the voltage-ion probe reader (VIPR) for FRET measurement and consisting of two dyes, coumarin-linked phospholipid CC2-DMPE, which acts as a donor, and an oxonol dye DiSBAC2, which acts as an acceptor. .