Detail of "4784-40-1"

CAS Number:
4784-40-1
Name:
10H-Phenothiazine-10-propanamine,N,N,b-trimethyl-, 5,5-dioxide,hydrochloride (1:1)
Molecular Structure:
Formula:
C18H22 N2 O2 S . Cl H
Molecular Weight:
366.90542
Synonyms:
10H-Phenothiazine-10-propanamine,N,N,b-trimethyl-, 5,5-dioxide, monohydrochloride(9CI); Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-, 5,5-dioxide,monohydrochloride (8CI); Oxomemazine hydrochloride
Density:
g/cm³
Boiling Point:
492.4°Cat760mmHg
Flash Point:
251.6°C

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Colloidal, partition, and binding properties of phenothiazine derivatives, Part 1: Colloidal, partition, and binding properties of phenothiazine derivatives, Part 1. Relations between chemical structure and molecular association. Thoma, Karl; Arning, Manfred (Inst. Galenische Pharm., Johann Wolfgang Goethe-Univ., Frankfurt/Main, Ger.). Arch. Pharm. (Weinheim, Ger.), 309(10), 837-50 (German) 1976. CODEN: ARPMAS. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The surface activity of 18 phenothiazine (I) derivs. was influenced by both C-2 and N-10 substitution, and increased with C-2 substituents in the order OMe < H < Cl < SMe < CF3. Oxidn. of the ring S made the mol. so strongly hydrophilic that the surface activity was almost completely lost. Crit. micelle concns. (c.m.c.) for the derivs. ranged from 2 .times. 4784-40-1 and 3403-42-7 which are cas registry numbers of chemicals are mentioned. 10-3 mol/L for thiethylperazine dimaleate [1179-69-7] to 2.1 .times. 10--2 mol/L for homofenazine dihydrochloride [1256-01-5]. Addn. of NaCl caused a linear decrease in the log c.m.c. with increasing log of the counterion concn. .