Reference

Pharmaceutical preparation for treatment of trigeminal neuralgia

Pharmaceutical preparation for treatment of trigeminal neuralgia. Steinbach, Karl (Fostieris, Nicolas, Ger.). Ger. Offen. DE 2609920 15 Sep 1977, 3 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-52. APPLICATION: DE 76-2609920 10 Mar 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A compn. of treatment of trigeminal neuralgia contains phenyldimethyl-isopropyl-pyrazolone 90, 1-phenyl-2,3-dimethyl-4-isopropyl-5-pyrazolone [479-92-5] 150, Na phenyldimethylpyrazolone aminomethanesulfonate [129-89-5] 35, 4-ethoxyacetanilide [62-44-2] 150, .beta.-hydroxybutryl-p-phenetidine [1083-57-4] 30, phenacetin [62-44-2] 150, caffeine [58-08-2] 30, aneurine-nitrate [532-43-4] 5, a vehicle (360 mg) contg. dextrose and Na alginate, and other inert ingredients.

Shelf-life influence on disintegration and hardness of propyphenazone-metamizol tablets containing surfactants

Shelf-life influence on disintegration and hardness of propyphenazone-metamizol tablets containing surfactants. Duric, Milijana; Jovanovic, M.; Duric, Z. (Galenika, Pharm. and Chem. Ind., Belgrade 11000, Yugoslavia). Pharmazie, 41(9), 665-6 (English) 1986. CODEN: PHARAT. ISSN: 0031-7144. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The hardness of tablets contg. propyphenazone (I) [479-92-5] and metamizol (II) [68-89-3] decreased with increasing storage times, both in the presence and absence of surfactants, i.e.There are some commonly used reagents with their cas registry numbers 151-21-3 and 68-89-3 in this article., Tween 80 [9005-65-6], Na lauryl sulfate [151-21-3] and Na dioctyl sulfosuccinate [577-11-7]. Such a decrease in hardness, which was not always correlated with tablet disintegration time, was attributed to the decrease in adhesion bonds. This change cannot be explained by the surfactant presence since the decrease of hardness is noticed with the samples without surfactants as well. .