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Basic Information
| CAS No.: | 480-54-6 |
|---|---|
| Name: | RETRORSINE |
| Article Data: | 2 |
| Molecular Structure: | |
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| Formula: | C18H25 N O6 |
| Molecular Weight: | 351.4 |
| Synonyms: | Retrorsine(6CI,7CI,8CI); Senecionan-11,16-dione, 12,18-dihydroxy-; NSC 107659; Retrorsin;[1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione,3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl-,[5R-(3Z,5R*,6S*,14aR*,14bR*)]-; b-Longilobine |
| Density: | 1.32±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point: | 208-211oC(lit.) |
| Boiling Point: | 583.169°C at 760 mmHg |
| Flash Point: | 306.49°C |
| Risk Codes: | R25 |
| Safety: | Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 96.30000 |
| LogP: | 0.10310 |
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RETRORSINE
Chemistry
Molecular Formula:C18H25NO6
Molecular Weight:351.44
Mp:208-211 °C(lit.)
Merck:13,8253
Properties:Crystals from ethyl acetate.
Retrorsine's Synonyms: BETA-LONGILOBINE;12,18-DIHYDROXYSENECIONAN-11,16-DIONE;RETRORSIN;RETRORSINE;16-dione,12,18-dihydroxy-senecionan-1;5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-hydroxymethyl-5-3-ethylidene-4;cis-retronecicacidesterofretronecine;methyl(1,6)dioxacyclododeca(2,3,4-gh)pyrrolizidine-2,7-dione
Molecular Weight:351.44
Mp:208-211 °C(lit.)
Merck:13,8253
Properties:Crystals from ethyl acetate.
Retrorsine's Synonyms: BETA-LONGILOBINE;12,18-DIHYDROXYSENECIONAN-11,16-DIONE;RETRORSIN;RETRORSINE;16-dione,12,18-dihydroxy-senecionan-1;5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-hydroxymethyl-5-3-ethylidene-4;cis-retronecicacidesterofretronecine;methyl(1,6)dioxacyclododeca(2,3,4-gh)pyrrolizidine-2,7-dione
Toxicity Data With Reference
| 1. | ctr-ham:kdy 25 µg/L | CRNGDP Carcinogenesis. 1 (1980),161. | ||
| 2. | sln-dmg-par 10 mmol/L | JOGNAU Journal of Genetics. 59 (1966),273. | ||
| 3. | orl-rat LDLo:30 mg/kg | JPBAA7 Journal of Pathology and Bacteriology. 78 (1959),471. | ||
| 4. | ipr-rat LD50:34 mg/kg | CBINA8 Chemico-Biological Interactions. 5 (1972),227. | ||
| 5. | ivn-rat LD50:38 mg/kg | RETOAE Research Today. 5 (1949),53. | ||
| 6. | ivn-mus LD50:59 mg/kg | RETOAE Research Today. 5 (1949),53. | ||
| 7. | orl-mam LDLo:33 mg/kg | PAREAQ Pharmacological Reviews. 22 (1970),429. |
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 ,1976,p. 303.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .
Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Retrorsine's Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 22-36/37/39-45
RIDADR 1544
RTECS VH7525000
HazardClass 6.1(a)
PackingGroup II