Detail of "4806-79-5"

CAS Number:
4806-79-5
Name:
Benzeneethanamine,4-chloro-b-methyl-
Superlist Name:
2-(4-Chlorophenyl)propan-1-amine hydrochloride
Molecular Structure:
Formula:
C9H12 Cl N
Molecular Weight:
169.6513
Synonyms:
Phenethylamine,p-chloro-b-methyl- (7CI,8CI);2-(4-Chlorophenyl)-1-propylamine; 2-(4-Chlorophenyl)propan-1-amine; 2-(4-Chlorophenyl)propylamine;2-(p-Chlorophenyl)propylamine; p-Chloro-b-methylphenylethylamine
EINECS:
225-365-5
Density:
1.093 g/cm³
Boiling Point:
243.3 °C at 760 mmHg
Flash Point:
116.2 °C

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Selective inhibition of monoamine oxidase A and B by two substrate analogs, 5-fluoro-a-methyltryptamine and p-chloro-b-methylphenethylamine: Selective inhibition of monoamine oxidase A and B by two substrate analogs, 5-fluoro-a-methyltryptamine and p-chloro-b-methylphenethylamine. Kinemuchi, Hiroyasu; Arai, Yuichiro (Sch. Med., Showa Univ., Tokyo 142, Japan). Res. Commun. Chem. Pathol. Pharmacol., 54(1), 125-8 (English) 1986. CODEN: RCOCB8. ISSN: 0034-5164. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In order to develop new and potent reversible monoamine oxidase (MAO) [9001-66-5] inhibitors selective for type B enzyme, the inhibitory effects of 2 substrate analogs, 5-fluoro-a-methyltryptamine (5-FMT) [712-08-3] and p-chloro-b-methylphenethylamine (p-CMP) [4806-79-5] on rat brain MAO-A and -B activity in vitro were examd. Studies of the inhibitory effects of both analogs showed that 5-FMT was a highly MAO-A-selective inhibitor, whereas p-CMP was a highly MAO-B-selective inhibitor. The degree of inhibition by 5-FMT or p-CMP was not enhanced by extending the time of preincubation of the enzyme and either analog. Diln. 4806-79-5 and 9001-66-5 are just another two chemicals used in this study. studies revealed the inhibition to be reversible in nature, indicating that both analogs are reversible MAO-A-selective (5-FMT) or -B-selective inhibitor (p-CMP) with high selectivity. .