Reference

Different effects of enantiomers of tetrahydropalmatine on dopaminergic system

Different effects of enantiomers of tetrahydropalmatine on dopaminergic system. Jin, Guozhang; Xu, Shouxi; Yu, Leiping (Shanghai Inst. Mater. Med., Acad. Sin., Shanghai, Peop. Rep. China). Sci. Sin., Ser. B (Engl. Ed.), 29(10), 1054-64 (English) 1986. CODEN: SSBSEF. ISSN: 0253-5823. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The d- [3520-14-7] and l- [483-14-7] isomers of tetrahydropalmatine (THP) had different effects on the brain dopaminergic system. Using [3H]spiperone for dopamine (DA) [51-61-6] receptor binding assay, it was found that l-THP had an affinity to DA receptors with ki of 0.2 mM. Neither d-THP nor reserpine showed similar affinity even at concns. >100 and 1000 mM. Based on the fact that the presynaptic DA receptors take part in feed-back regulation on tyrosine hydroxylase activity, DOPA [59-92-7] accumulation could be obsd. in rat striatum after injection of benserazide. A small dose of l-THP (2.5, 5, 10 mg/kg, i.p.) caused an elevation of DOPA level by 49-282% vs. the control value, and could reverse the decrease of DOPA level induced by apomorphine, a DA receptor agonist. On the contrary, d-THP displayed a biphasic effect on DOPA level, slight decrement (26-37%) at 10 and 25 mg/kg, no change at 50 mg/kg, and a 91% increment at 100 mg/kg, which was less than that obsd. with l-THP at 5 mg/kg.There are some commonly used reagents with their cas registry numbers 59-92-7 and 102-32-9 in this article. DOPAC [102-32-9] level in the striatum was increased by 88 or 190% at 2.5 or 10 mg/kg, resp. l-THP at 50-100 mg/kg reduced DA level by 24-26%. However, the DA content redn. induced by d-THP is much more dose-dependent. At a small dose (10 mg/kg), d-THP predominately reduced the DA level but left 5-HT and NA level unaffected. It caused an 80% redn. of DA at 100 mg/kg. The results indicated that l-THP is a DA receptor antagonist, whereas d-THP is probably a DA depletor. .

Study on the utilization of medicinal plant resources of the genus Stephania of the family Menispermaceae in China

Study on the utilization of medicinal plant resources of the genus Stephania of the family Menispermaceae in China. Zhu, Zhaoyi; Feng, Yuxiu; Ho, Liyi; Wang, Yanchun (Inst.Some chemicals with cas registry numbers like 436-05-5 and 518-94-5 are also used. Mater. Med., Chin. Acad. Med. Sci., Beijing, Peop. Rep. China). Yaoxue Xuebao, 18(6), 460-7 (Chinese) 1983. CODEN: YHHPAL. ISSN: 0513-4870. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 11 Total alkaloid contents in the root or bulb of S. delavayi, S. japonica, S. longa, S. tetrandra, S. excentrica, S. cepharantha, S. epigaea, S. brackyandra, S. sinica, S. dielsiana, S. yunnanensis, S. succifera, S. hainanensis, S. mashanica, S. micrantha, S. dicentrinifera, S. kwangsiensis and S. viridiflavens were 3.10, 0.19, 0.86, 2.96, 19.65, 1.52, 2.96, 6.65, 2.04, 2.62, 5.16, 2.32, 2.44, 2.00, 1.00, 4.20, 2.62 and 6.00% resp. Contents of l-tetrahydropalmatine [483-14-7], l-dicendrine [517-66-8], isocorydine [475-67-2], cepharanthine [481-49-2], tetrandine [518-34-3], isotetrandrine [477-57-6], cycleanine [518-94-5], homoaromoline [17132-74-0], berbamine [478-61-5] and l-curine [436-05-5] also were detd. This method may be used in the chemotaxonomy of Stephania. .