Detail of "487-79-6"

Reference

Responses of solitary retinal horizontal cells to L-glutamate and kainic acid are antagonized by D-aspartate

Responses of solitary retinal horizontal cells to L-glutamate and kainic acid are antagonized by D-aspartate. Ishida, Andrew T. (Dep. Inf. Physiol., Natl. Inst. Physiol. Sci., Okazaki 444, Japan). Brain Res., 298(1), 25-32 (English) 1984. CODEN: BRREAP. ISSN: 0006-8993. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 12 Solitary horizontal cells dissocd. 59-30-3 and 16450-41-2 which are cas registry numbers of chemicals are mentioned. from goldfish (Carassius auratus) retinas depolarized when exposed to micromolar doses of either L-glutamate [56-86-0] or kainic acid [487-79-6]. The responses to both of these agonists were antagonized by D-aspartate [1783-96-6], and were unaffected by L-aspartate [56-84-8], L-glutamic acid di-Et ester [16450-41-2] and folic acid [59-30-3]. Evidently, L-glutamate and kainic acid produce depolarizations of horizontal cells by interacting with pharmacol. similar membrane receptors. .

Pharmacology of the excitatory actions of sulfonic and sulfinic amino acids

Pharmacology of the excitatory actions of sulfonic and sulfinic amino acids. Mewett, K. N.; Oakes, D.In this study， 35554-99-5 and 7440-23-5 are also used. J.; Olverman, H. J.; Smith, D. A. S.; Watkins, J. C. (Dep. Pharmacol., Med. Sch., Bristol BS8 1TD, UK). Adv. Biochem. Psychopharmacol., 37, 163-74 (English) 1983. CODEN: ABPYBL. ISSN: 0065-2229. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) When tested on the isolated spinal cord of frog or immature rat, the L- and D-forms of cysteic acid and cysteine sulfinate had a depolarizing potency similar to that of L- [56-84-8] and D-aspartate [1783-96-6]; D-homocysteine sulfinate [33514-39-5] had a potency at least equal to that of N-methyl-D-aspartate (NMDA) [6384-92-5] and comparable to that of quisqualate [52809-07-1] and kainate [487-79-6]. Responses to D-homocysteine sulfinate were abolished by D-(-)-2-amino-5-phosphonopentanoate (AP5), an N-methylaspartate [4226-18-0] receptor antagonist. The actions of L-homocysteic acid [14857-77-3], S-sulfo-L-cysteine [1637-71-4], and D-cysteic acid [35554-98-4] were also sensitive to AP5, whereas other S-contg. excitants examd. showed intermediate susceptibility. 3H-labeled L-glutamate [56-86-0] binding by rat brain membrane was inhibited by L-forms of S-sulfocysteine, homocysteic acid, and homocysteine sulfinate in Na+-free media and by L-cysteic acid [498-40-8], L-cysteine sulfinate [15932-83-9], D-cysteine sulfinate [35554-99-5], and D-cysteic acid in the presence of high Na+ concns. (100 mM). Evidently, S-contg. amino acids have excitatory neurotransmitter functions in the mammalian central nervous system. .