Detail of "

491-67-8

CAS Number:
491-67-8
Name:
4H-1-Benzopyran-4-one,5,6,7-trihydroxy-2-phenyl-
Superlist Name:
Baicalein
Molecular Structure:
Formula:
C₁₅H₁₀O₅
Molecular Weight:
270.24
Synonyms:
Baicalein(6CI);Flavone, 5,6,7-trihydroxy- (7CI,8CI);5,6,7-Trihydroxyflavone;NSC 661431;Noroxylin;
Density:
1.548 g/cm³
Melting Point:
256-271 °C(lit.)
Boiling Point:
575.932 °C at 760 mmHg
Flash Point:
225.257 °C
Appearance:
Yellow crystalline solid
Hazard Symbols:
Xi,Xn
Risk Codes:
36/37/38-20/21/22
Safety:
26-36 Details

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Reference

Studies on Scutellariae Radix: Studies on Scutellariae Radix. XII. Anti-thrombic actions of various flavonoids from Scutellariae Radix. Kubo, Michinori; Matsuda, Hideaki; Tani, Tadato; Arichi, Shigeru; Kimura, Yoshiyuki; Okuda, Hiromichi (Fac. Pharm. Sci., Kinki Univ., Higashi-Osaka 577, Japan). Chem. Pharm. Bull., 33(6), 2411-15 (English) 1985. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The flavonoid components baicalein [491-67-8], baicalin [21967-41-9], wogonin [632-85-9], wogonin-7-O-D-glucuronide [51059-44-0], oroxylin A [480-11-5], skullcapflavone II [55084-08-7], chrysin [480-40-0], (2S)-2',5,6',7-tetrahydroxyflavanone [80604-16-6]-, and (2R,3R)-2',3,5,6',7-pentahydroxyflavanone [80366-15-0], obtained from the roots of S. baicalensis were screened in comparison with 2 std. antithrombic agents, aspirin and heparin, for activity in exptl. models of blood platelet aggregation or conversion of fibrinogen to fibrin. Baicalein, wogonin, oroxylin A, skullcapflavone II, and chrysin at a concn. of 1.0 mM inhibited collagen-induced blood platelet aggregation. Chrysin also inhibited ADP-induced blood platelet aggregation. In the case of arachidonic acid-induced blood platelet aggregation, biacalein and wogonin had an inhibitory action. Baicalein and baicalin among the test substances inhibited the conversion of fibrinogen to fibrin induced by thrombin. The effects of baicalein and baicalin on the exptl. disseminated intravascular coagulation (DIC) induced by endotoxin in rats were examd.; both compds. prevented the decrease of blood platelets and fibrinogen in DIC rats.

Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase: Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase. Friedman, Fred K.; West, Donna; Sugimura, Takashi; Gelboin, Harry V. (Lab. Mol. Carcinog., Natl. Cancer Inst., Bethesda, MD 20205, USA). Pharmacology, 31(4), 203-7 (English) 1985. CODEN: PHMGBN. ISSN: 0031-7012. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) A series of 18 flavone modulators of aryl hydrocarbon hydroxylase (AHH) [9037-52-9] were employed to distinguish and probe for different cytochrome P 450 [9035-51-2] isozymes in liver microsomes from control and 3-methylcholanthrene (MC)-injected rats. Some flavones [maackiain acetate (I) [2035-16-7], flavanone [487-26-3], mollisacacidin [967-27-1], embinin [52589-13-6], sciadopitysin [521-34-6]] activated, whereas most of the tested compds. inhibited the MC-induced type of AHH. Although all flavones either inhibited or had little effect on the constitutive AHH in microsomes from control rats, the degree of inhibition varied greatly: some flavones (chrysin [480-40-0], chrysoeriol [491-71-4], baicalein [491-67-8], I, isoliquiritigenin [961-29-5], sciadopitysin) inhibited >75% of the AHH. The various flavones screened may prove useful in defining the cytochrome P 450 content of tissues and for probing the active sites of individual isozymes. The modulatory effects of the naturally occurring flavones assume addnl. importance in that they may be factors in animal and human responsiveness to cytochrome P 450 substrates.

491-67-8

4H-1-Benzopyran-4-one,5,6,7-trihydroxy-2-phenyl-

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Reference